Nishita Kalepalli

- Collaborate with physician-scientists to analyze large-scale genomic and clinical data from the All of Us/UK Biobank cohorts with R/Python - Developed GWAS, PheWAS, and PRS pipelines, with regression analysis to identify disease-related SNPs in datasets of 500,000 individuals - Implemented CHiCAGO/Chicdiff pipelines to identify differential SOX2 promoter interactions in a micro-C dataset with 2.3 million interactions - Analyzed single-cell PBMC data with Seurat, uncovering macrophage differential expression of cellular senescence genes - Conducted targeted/untargeted metabolomics analysis on 2,500 metabolites, identifying 3 enriched pathways associated with delirium - Applied k-means, model-based clustering (mclust), and hierarchical clustering on a pulmonary embolism dataset of 36 patients, identifying key clinical variables from 485 features to define patient outcomes

Undergraduate Researcher aiding Lee Lab Project Goal: Comparing Maternal Clearance in Xenopus species (Xenopus laevis and Xenopus tropicalis) - Obtained data sets through SRA database - Quantified gene expression with Kallisto - Compare and analyze large data sets using R and python

Undergraduate Researcher aiding Hildebrand Lab (Neural Defects: Wet lab) Project Goal: Understanding the effect of tropomyosin gene mutations on fruit flies - Created fruit fly crosses to achieve desired mutations - Dissected fruit fly wings - Examined large data sets using Microsoft Excel

- COVID-19 and Health Education Committee: Collaborate with other members to increase awareness about health and sanitation in the village of Tatipaka, India

- Member of Programming Committee - Organize events to promote member engagement in fraternity

Undergraduate Researcher at Koes Lab Project #1: Nitric Oxide Synthase and Chronic Pain - Identified proteins involved in the NMDA receptor transduction pathway - Identified small molecules that could potentially inhibit proteins in the pathway - Conducted molecular docking - Analyzed ligand binding visually through PyMOL - Calculated affinity scores using smina (Scoring and Minimization with AutoDock Vina) Project#2: Frataxin/ISCU Complex and Friedreich's Ataxia - Examined latest literature on Frataxin/ISCU Complex and their role in regulating Iron and Oxygen - Performed MD pocket analysis of Frataxin protein and ISCU complex

Undergraduate Researcher aiding Turcotte Lab of Evolutionary Ecology (Wet Lab) Project Goal: Understanding the effect of chemical stressors on duckweed populations - Experimented on Lemna minor and Spirodela polyrhiza species with Iron Chloride - Compared large datasets using Microsoft Excel to study growth rates

Minor: Chemistry

IB Diploma Top Scorer