Nicole Reinhold-Larsson, PhD
Scientist I @ DoriNano
About
I am a PhD scientist with deep expertise in immunology who is passionate about advancing new drugs and therapies that improve the lives of patients. My experience spans academic research and early-stage biotech, where I have contributed to innovative projects leveraging the immune system to combat a variety of diseases across different therapeutic areas. In addition to my scientific work, I am a dedicated mentor committed to supporting the next generation of scientists, an endeavor that has shaped me into a thoughtful leader and effective communicator.
United States
Boston
Research
Dissection, Ex Vivo, Cell Based Assays, In Vivo, Subcutaneous Injections, Multi-color Flow Cytometry, Transfection, Transduction, Tissue Culture, Western Blotting, Molecular Cloning, Flow Cytometry, qPCR, ELISA, PBMC isolation, Biosafety Lab 3 Training, Biosafety Lab 2 Training, Mouse Models
Experience
Scientist I
DoriNano
Cambridge, MA
Scientist
StiRx Inc
Cambridge, MA
▪ Developed a scientific and technical foundation for a bispecific antibody therapy including target identification and prototype design by directly collaborating with the CEO and founder ▪ Devised and presented a pre-clinical research strategy for early proof-of-concept prototype testing to the Scientific Advisory Board (SAB) ▪ Independently developed, optimized, and executed ELISAs to validate bsAb target engagement
Postdoctoral Scientist
Harvard University
Boston, Massachusetts, United States
▪ Continuation of graduate work while mentoring one technician; one first-author publication in progress
PhD Student
Harvard University
Boston, MA
▪ Led the development of an in vitro model and leveraged a mouse infection model to uncover type I IFN–dependent PD-L1 upregulation that impairs CD8⁺ T cell memory during Chlamydia trachomatis infection ▪ Collaboratively built and validated a lentiviral expression library of effector proteins from C. trachomatis ▪ Trained and managed 1 full time technician and 2 summer undergraduate interns on 3 separate projects ▪ Delivered scientific and mentorship presentations to diverse audiences at international and national conferences ▪ Led the conceptualization and writing of a successful NIH R21 grant ($275k) and R01 supplement grant ($70k)
Undergraduate Student Research Assistant
The Ohio State University Wexner Medical Center
Columbus, Ohio Area
Laboratory of Dr. Namal Liyanage ▪ Utilized spectral flow cytometry (Cytek Aurora) and intracellular cytokine staining to identify natural killer (NK) cells and innate lymphoid cell (ILC) populations in SIV infected rhesus macaque (NHP) samples • Presented posters at 2 Ohio State undergraduate research symposiums and at the Annual Biomedical Research Conference for Minoritized Students (ABRCMS, received presentation award)
Undergraduate Student Research Assistant
The Ohio State University Wexner Medical Center
Columbus, Ohio Metropolitan Area
Laboratory of Dr. Jordi Torrelles • Assisted graduate students and technicians in peripheral blood mononuclear Cell (PBMC) isolation, macrophage differentiation and culturing, confocal microscopy, and biosafety level 3 (BSL3) experiments with Mycobacterium tuberculosis • Lead lab maintenance duties and cleaning
Undergraduate Researcher in the Summer Honors Undergraduate Research Program (SHURP)
Harvard Medical School
Greater Boston Area
Laboratory of Dr. Michael Starnbach • Identified innate and adaptive immune cell populations and cytokine secretion in infected mice using multi-color flow cytometry and Enzyme-Linked Immunosorbent Assay (ELISA) • Presented 2 posters and 3 oral presentations (received presentation award at Society for the Advancement of Chicanos/Hispanics and Native Americans in STEM (SACNAS) conference
Undergraduate Research Assistant in the Research Experience for Undergraduates (REU) Program
University of Iowa Roy J. and Lucille A. Carver College of Medicine
Iowa City, Iowa Area
Research Experience for Undergraduates (REU) student in the laboratory of Dr. Craig Ellermeier • Utilized site-directed mutagenesis to clone and characterize the β-galactosidase activity of 16 Bacillus subtilis mutants • Presented a poster at the university wide undergraduate research conference
Education
Harvard University
Biological and Biomedical Sciences
The Ohio State University
Microbiology
Nicole Reinhold-Larsson, PhD's Contact Information
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