Nathan Will
Scientist II, Biophysics @ Treeline
United States
Sherborn
Biotechnology
Data Analysis, Research Skills, Light Scattering, Liquid Chromatography-Mass Spectrometry (LC-MS), Molecular Biology, Tissue Culture, Membrane Proteins, Cryogenic Electron Microscopy, Structural Biology, Protein Labeling, Protein Structure, Presentations, Material Characterization, Design of Experiments (DOE), Cell Culture, Protein Expression, Experimental Design, Western Blotting, Polymerase Chain Reaction (PCR), Protein Characterization
Experience
Scientist II, Biophysics
Treeline
Watertown, MA
Senior Scientist, Protein Biochemistry
Evolved By Nature
Needham, Massachusetts, United States
Postdoctoral Scientist
The Rockefeller University
New York, New York, United States
• Developed expression and purification protocol of the mechanosensitive membrane protein YnaI for structural studies • Utilized cryo-electron microscopy to determine the structure of YnaI in detergent as well as reconstituted into nanodiscs with different mutations or lipid environments to gain mechanistic insights into YnaI activitiy • Engineered a truncated YnaI construct (which previous efforts failed to express) by designing a chimera with a related protein, MscS, to determine the structure-function relationships in YnaI. • Determined the structure of Aquaporin 9 by cryo-electron microscopy in detergent as well as reconstituted in nanodiscs • Utilized MACS and flow cytometry to identify high affinity monovalent single-chain camelid antibodies (nanobodies) from a yeast display library
Associate Researcher
Icahn School of Medicine at Mount Sinai
New York, New York, United States
• Optimized protocols to express and purify homologs of the Alzheimers linked membrane protein Presenillin • Prepared protein samples for the 2D crystallization pipeline of the Transcontinental Electron Microscopy Initiative for Membrane Protein Structures (TEMIMPS) Consortium.
Education
The Graduate Center, City University of New York
Biochemistry
• Structural characterization of eukaryotic elongation factor 2 kinase (eEF-2K) activation • Utilized an array of biophysical techniques (including NMR, SAXS, circular dichroism, chemical crosslinking and Hydrogen/Deuterium exchange (HDX) mass spectrometry, and native mass spectrometry) to investigate structure-function relationships of eEF-2K activation • Used NMR to determined the structure of a region of eEF-2K that recruits eEF-2 to the kinase
Weill Cornell Graduate School of Medical Sciences
Biochemistry, Cellular and Molecular Biology
• Worked characterized the effect of a common SNP (V66M) of brain-derived neurotrophic factor (BDNF) on its relative affinity to two proteins (sortilin and SorCS2) know to traffic BDNF to different areas of the neuron • Designed an immunoprecipitation assay using 293T cells cotransfected with proBDNF, sortilin and SorCS2 as a model system • Designed and generated an expression vector to express and purify the pro-domain of BDNF for NMR studies.
Alfred University
Chemistry
Undergraduate research experience preparing various glass samples for protein crystallization or bioactivity testing
Nathan Will's Contact Information
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