Micol Marchetti Ph.D

Preclinical Team Leader @ ViaNautis

About

Hi, I'm Micol, Preclinical Team Leader with a wide spectrum of skills developed thanks to an extensive experience lab-based within the cardiovascular and renal field. My skills allow me to bridge in-vitro and in-vivo studies in the pre-clinical and early drug discovery phases. I have a proven track record as study director for pre-clinical studies focusing on general bio-distribution and CNS. Cell culture, primary cell culture, protein over-expression, silencing, and analysis are in-vitro skills with which I’m familiar on top of IHC, confocal and bright field, RNA/DNA analysis via qPCR and ddPCR. In terms of managerial skills, pre-clinical project management, vendors managements, Academic collaborations driver, and documents management (scope of work definition, reporting, risk mitigation and gap analysis) are skills that I have been able to develop co-leading cross-departmental core-teams. I curious and passionate, focused on delivering robust data packages in a fast moving and innovative environment. I am looking for supporting and improving the processes and bringing experience and troubleshooting capacity to minimize potential impacts on deliverables. I highly value the strength of multi-departmental teams and their richness, and I take seriously the opportunity to mentor and develop further Juniors members being able to understand the value of working with engaged, positive and curious colleagues feeling empowered to develop themselves. My Motto: analyze, improvise, adapt, and overtake. Lab based skills: • In-vitro: cell culture, primary cell isolation and culture, protein overexpression and inhibition, ELISA, proliferation, angiogenesis Assay, migration Assay, Luciferase Assay • In-vivo • Ex-vivo: RNA/DNA analysis via qPCR/ddPCR • Basic FACS • IHC: IHC and IF (bright field and confocal, paraffin and OCT) • Protein analysis • Product characterization Management skills • Study director (study design and management) • Risk assessment & mitigation • Gap analysis • Troubleshooting • Project management (project initialization, deliverables, time frame, documents) • Global Vendor and Academic Collaborations management (Evotec, Invicro, University of Oxford, LabCorp, MDC) • Hiring and line-management • Training • SOPs review and co-author

Country

United Kingdom

City

Cambridge

Industry

Higher Education

Skill

Biodistribution, CRO Management, Cross-team Collaboration, Immunocytochemistry, RNA analysis, RNA Isolation, Pre-clinical Studies, Ex Vivo, Line Management, Leadership, English, Research, Drug Discovery, Data Collection, Fluorescence Microscopy, Microsoft PowerPoint, Mammalian Cell Culture, Polymerase Chain Reaction (PCR), Data Analysis, Teamwork

Experience

Preclinical Team Leader

ViaNautis

2024-1 - Present · 2 yrs 9 mos

Cambridge

Senior Translational Scientist -

Evox Therapeutics Ltd

2021-7 - 2023-9 · 2 yrs 3 mos

Oxford, England, United Kingdom

Currently responsible for the exploratory work linked to CNS delivery of siRNA and ex-vivo molecular pathology. Skills currently in use: 1) Study director/study coordinator for in-vivo linked to CNS delivery 2) ex-vivo molecular pathology analysis (RNA/DNA, qPCR/ddPCR) 3) Tissue Analysis ' protocols troubleshooting and development

Research Scientist

Evox Therapeutics Ltd

2019-6 - 2021-7 · 2 yrs 2 mos

Oxford

As a Research Scientist, I have delivered strategic leadership to a team of two junior members and encouraged them to achieve set goals while functioning as line manager. I have arranged effective training and development sessions for staff to boost knowledge and performance. I have acted as SME for an AKTA machine to manage operational aspects of in-vivo work with CROs and collaborators. I have liaised with Fair Journey to develop antibodies. My Key Accomplishments ♦ Led collaboration with the University of Oxford based on ex-vivo perfusion of study material in human liver. ♦ Produced and characterised the study material and analysed samples derived from the treated organs.

Postdoctoral Researcher

Uppsala University

2017-6 - 2019-5 · 2 yrs

Sweden

As a Wenner-Gren Postdoctoral Researcher, I have provided research support in preparation of dissertation as SME of IHC techniques, line-manager of two summer and medical students. I have invited as a speaker for the Europhysiology 2018 while preparing preliminary data. My Key Accomplishments ♦ Learned pressure myography technique required for the post-doc and established immunohistochemistry (IHC) protocols for the first time in the physiology team. T ♦ Headed and completed project based on browning and ageing. ♦ Received invitation as a speaker to the Europhisiology Meeting in 2018.

Honorary Research Associate

Bristol University

2017-1 - 2017-5 · 5 mos

Bristol Royal Infirmary

Post-Doctoral Researcher - Research Associate

Renal Unit, School of Clinical Sciences, Bristol

2013-11 - 2016-12 · 3 yrs 2 mos

Academic Renal Unit, Bristol

In my role as Research Associate, I have administered various research activities from in-vitro to in-vivo, RNA extraction and qPCR, proteins extraction, and western blots. I have worked with colonies of mice to evaluate proteinuria and, on tissues, performed IHC analysis, qPCR for down-stream genes and western blot. My Key Accomplishments ♦ Developed and deployed single cell suspension technique to manage and study three different animal colonies based on over 60 animals. ♦ Created protocol aimed to produce single cells suspension from kidney glomeruli critical for cell sorting and improved a protocol for primary culture of podocyte in-vitro.

Research Collaborator

Bristol Heart Institute

2012-1 - 2013-11 · 1 yr 11 mos

Bristol, Regno Unito

As a Research Technician, I have contributed to successful execution of application to screen 25 microRNAs in human critical limb ischemia (CLI) with research sample size of 50. Planned and controlled budget to secure maximum profitability. I have worked with in-vitro model of ischemia, diabetes and combined those two. I have attained grant by UK Diabetes over £165,754 based on innovative research proposal. My Key Accomplishments ♦ Produced the data for a UK Diabetes grant and for a 3rd price for a poster session based on the screening of 25 microRNAs on a population of 50 human samples.

Advanced training fellowships

University of Modena and Reggio Emilia

2006-1 - 2007-1 · 1 yr 1 mo

Modena

Study of the effects of exposure to ELF electromagnetic fields covered by the cell membrane of peripheral blood lymphocytes of workers occupationally exposed Keywords: blood analysis, proteins analysis, IHC, in-vivo cultivar, western blot.