Mariana Garcia Mendonça Lopes, PhD

Designed and optimized fluidic systems for medical devices including sample insertion. Performed fluid modeling, validation testing, and data analysis to improve system performance. Collaborated with multidisciplinary teams and prepared technical documentation in compliance with ISO 13485 standards.

Design, prototype, and test microfluidic discs for point‑of‑care diagnostic devices. Develop CAD models and iterate designs using Fusion 360, supporting rapid prototyping cycles. Fabricate microfluidic components using 3D printing, CNC micromilling, and laser cutting, reducing development lead time. Execute ISO 13485 design control activities, including documentation, verification, and traceability for medical devices. Development and implementation of Python scripts using OpenCV and Numpy for automated cell counting and data analysis. Collaborate with cross‑functional R&D teams to support product development and technology transfer.

Led the development of microfluidic platforms for neural organoid growth and drug discovery within an EU‑funded project. Designed and fabricated PDMS microfluidic devices with microwells for controlled neurospheroid formation. Conducted cell culture, viability assays, and performance testing in microfluidic environments. Engineered hydrogel‑based extracellular matrices to optimize cell growth and microenvironment conditions. Developed microcontact printing techniques for precise neurosphere patterning. Authored SOPs for microdevice fabrication, testing, and experimental workflows. Collaborated with biologists, chemists, and engineers in a multidisciplinary research environment.

Nanobioengineering Group - JS Conducted cell culture, viability assays, and performance testing in microfluidic environments. Fusion 360, CAD‑based for microdevice design. Prototyping microfluidic devices using 3D Printing (SLA). Microfabrication, PDMS molding, cleanroom processes, surface treatment.

C++ program development for estimation of oil kinetic parameters.

Developed an integrated microfluidic platform combining millireactors and microsensors for ethanol production and real‑time quantification. Designed and manufactured 3D‑printed millireactors with immobilized cells, improving process stability. Fabricated smart membranes and integrated them into PDMS microfluidic devices. Performed CFD simulations and experimental validation to optimize flow distribution and reactor performance. Managed multiple experimental workstreams, risk assessments, and data analysis activities. Research Papers: https://doi.org/10.1002/aic.17460

Conducted CFD simulations (Ansys CFX) to optimize biodiesel synthesis in millireactors. Designed and fabricated 3D‑printed millireactors for parallel chemical production. Assembled and tested reagent distributors and scaled‑up microfluidic systems. Research Papers: https://doi.org/10.1016/j.enconman.2019.01.090 https://doi.org/10.1016/j.cherd.2018.09.011

Specialized in PDMS microfluidic device fabrication using xurography. Applied CNC milling and laser cutting for rapid microdevice prototyping. Developed CAD designs for microfluidic components and tooling.

Performed laboratory testing of membrane filtration systems and prepared technical reports. Supported development of new applications for existing filtration products. Collaborated with customers, sales, and technical teams during product implementation.

Iniciação cientifica, monitoria e PET.