Mengyuan CAO

Project CARN-PEPR - Designed and synthesized hyaluronic acid- and aptamer-based targeting ligands for CD44-overexpressed macrophages targeting - Developed ligand functionalization strategies for LNP and EV surface engineering and validated in vitro targeting performance - Optimized LNP formulations to enhance targeted mRNA delivery efficiency.

Design and evaluation of drug-aptamer assemblies for targeted delivery to infectious and cancer diseases Project 1: Aptamer-based nanotrains and nanoflowers as quinine delivery systems - Designed and prepared aptamer-based nanotrains and nanoflowers as quinine carriers - Characterized carrier’s formation, drug loading ability, carrier stability and their in vitro safety profiles - Investigated targeting ability of carriers to the protein pfLDH and Plasmodium falciparum Project 2: Posaconazole-aptamer conjugates for the targeted delivery to lung fungal infections - Designed and prepared aptamer assemblies as posaconazole delivery carriers - Synthesized and purified Posaconazole-Linker conjugate - Investigated targeting ability of aptamers to (1, 3)-β-D-glucans and fungal species Project 3: Dual targeting of gastric cancer stem cells using aptamer-based nanomedicines - Designed and prepared bispecific anti-CD44 and anti-EpCAM aptamer assemblies - Investigated targeting ability of aptamers to gastric cancer stem cells.