mehabaw derebe

senior scientist, janssen biotherapeutics, janssen r and d

About

Biophysicist/protein chemist with expertise in therapeutic antibody discovery and early development assessment. Experienced in protein (antibody) reagent production, monoclonal/bicpecific antibodies, Fc engineering and Fc receptor in-vitro assays. Extensive experience in biophysical characterization using a variety of common methods. Background in structural biology (crystallography) of soluble and membrane proteins (ion channels). To connect: mehabawgd@yahoo.com, 4693288680

Country

united states

City

perkasie

Industry

pharmaceuticals

Skill

molecular cloning, pcr, mutagenesis, sds page, western blotting, protein chemistry, protein expression, protein purification, protein crystallization, protein structure, protein folding, membrane proteins, x ray crystallography, monoclonal antibodies, fab purification, ligand binding, mammalian cell culture, total mrna isolation and purification, cdna synthesis, qpcr, immunohistochemistry, microscopy, confocal microscopy, itc, microsoft office, hkl2000/3000, phenix, coot, ccp4, pymol, molecular biology, biochemistry, chromatography

Experience

senior scientist, janssen biotherapeutics, janssen r and d

the janssen pharmaceutical companies of johnson & johnson

2018-4 - Present · 8 yrs 6 mos

postdoctoral fellow

ut southwestern

2010-10 - 2015-3 · 4 yrs 6 mos

graduate research assistant

ut southwestern medical center

2004-8 - 2010-9 · 6 yrs 2 mos

lecturer of chemistry

addis ababa university

1998-9 - 2002-10 · 4 yrs 2 mos

* Taught freshman, sophomore and junior undergraduate chemistry classes. * Developed curriculum and exams. * Planned, organized and coordinated yearly summer schools for technicians from industry. * Synthesized and characterized new organometallic compounds.

scientist, janssen biotherapeutics at janssen r and d

the janssen pharmaceutical companies of johnson & johnson

2015-3 - 2018-3 · 3 yrs 1 mo

Fc engineering subgroup member in the Biologics Engineering and Function team of the Structural Biology group. . Collaborate with project teams in the various Therapeutic Areas (Oncology, Immunology, Cardiovascular/Metabolism, Infectious Diseases) to discover and develop a Biologic or small molecule therapeutic against a disease target. . Engineering and design of therapeutic proteins (antibodies, cytokines). . DNA construct design, expression, purification and analytical characterization of monocolonal antibodies (mAbs), Fc fusions, cell-surface receptors, cytokines of human or mouse origins. . Using GenMab's DuoBody technology, preparation and QC of bispecific antibodies. . Development of in-vitro Fc-receptor assays. . Platform/new technology development in collaboration with other scientists. . Document all experimental procedures, data, analysis and conclusion in an electronic laboratory notebook (ELN). . Backup metadata in centralized storage. . Critique colleague's experiments. . Organize data and write manuscripts for publication.