Mark Evan Goldman

Mark Evan Goldman, Ph.D. Was a pharmacologist at the Burnham Institute for Medical Research in La Jolla, CA. His 30+-year drug discovery background encompasses senior roles at Merck and Co. (West Point, PA), Ligand Pharmaceuticals (San Diego, CA) and Signal Pharmaceuticals (currently a division of Celgene Inc., San Diego, CA). Dr. Goldman’s experience at these institutions included leading the Merck Project Team that ultimately discovered and developed the non-nucleoside HIV reverse transcriptase inhibitor Efavirenz (Sustiva, licensed to Bristol-Myers Squibb) as well as numerous lead compounds for cancer (RAR/RXR-selective retinoids, Ligand Pharma), non-steroidal nuclear receptor agonists/antagonists (Ligand Pharma), NF-kB/AP-1 immunomodulators (Signal Pharma) and bioterror threats (PI for numerous NIH and US Department of Defense grants/contracts related to anthrax lethal factor inhibitors; Hawaii Biotech, Aiea, HI). He has served as a member of NIH counterbioterrorism study sections. He has published over 100 peer-reviewed papers and book chapters. In these roles, he also was involved in licensing drug candidates (both in-licensing and out-licensing). Dr. Goldman continues to maintain close relationships with key industry leaders at biotech companies as well as at major multi-national pharmaceutical companies. He received the Ph.D. degree in Pharmacology from The University of Texas at Austin and spent 5 years as a post-doc/senior staff fellow at the National Institutes of Health in Bethesda, MD. Some recent publications include: Goldman, M.E., Cregar, L, Nguyen, D, Simo, O, O’Malley, S and Humphreys, T. 2006 Cationic polyamines inhibit anthrax lethal factor protease. BioMedCentral Pharmacology 6 8-14. Jiao GS, Simo O, Nagata M, O’Malley S, Hemscheidt T, Cregar L, Millis SZ, Goldman ME,Tang C. 2006. Selectively guanidylated derivatives of neamine. Syntheses and inhibition of anthrax lethal factor protease. Bioorg. Med Chem Lettr. 16 5183-5189. Specialties: Outdoor and low light digital photography. No weddings