Zhong H.

Advanced discovery of novel probody-drug conjugate targets • Designed gene expression-based strategies for target discovery, and built target validation workflows • Submitted two internal invention disclosures for novel probody-drug conjugates and targets • Recruited and supervised a Ph.D. scientist

Affected by mass layoff at the Stemcentrx site

Led research efforts to discover novel combination therapies and ADC targets • Conducted large-scale in vitro screens, identified small molecules for combining with ADCs, and contributed to the patent on this combination therapy (US 11,027,021 B2) • Characterized two novel ADC targets (deprioritized due to expression heterogeneity in tumor)

Studied mouse hair follicle development by genetic lineage tracing and single-cell RNA sequencing. • Formulated a project from scratch, and findings led to the publication of a research article in Cell. • Conducted lineage tracing and transcriptional profiling of progenitor cells in the hair follicle matrix by utilizing in utero lentivirus transduction, FACS, and RNA sequencing.

Systematically investigated the role of Wnt/Frizzled planar cell polarity signaling in mammalian neural development and underlying mechanisms at molecular and cellular levels. • Discovered novel roles of Frizzled3 gene in mouse neural development at both neuroanatomical and behavioral levels, and the molecular mechanism underlying Frizzled3 signaling. • Developed whole-mount tissue immunohistochemistry staining combined with 3D confocal microscopy for visualizing axonal tracts and nerves. • Expressed and purified Cre recombinase protein in E. coli, and tested its recombination efficiency in cultured cells and in mice. • Tutored 82 Ph.D. students in quantitative population genetics for the Principles of Genetics course.

• Completed 4 research projects, and published 1 first-author and 3 co-author papers. • Created FindTar, a computational program for microRNA target prediction. • Uncovered novel principles of microRNA-mediated gene regulation.