Lingzhi Zhao
Vice President of R&D
About
• ~ 20 years of research and discovery in neuroscience, focusing on gene therapy and neuroimmunology • ~ 10 years of drug discovery experience across various modalities in multinational pharmaceutical companies and start-up biotechnology industry • ~ 8 years of experience in AAV gene therapy for CNS, ophthalmology, and oncology disorders • Proven project lead and team leader in program advancement, strategic portfolio setting, and program planning. • Initiated, led, or supported 3 programs that advanced into clinical trials, 4 programs to IND filing, and numerous preclinical programs to PCC. • Extensive experience in target identification and validation, nucleic acid CNS delivery, assay development and validation, and evaluating drug efficacy and safety. • Known for working diligently and efficiently to meet deadlines in fast-paced environments. • Self-motivated team player and strong leadership abilities
United States
Boston
Pharmaceuticals
Presentations, Cell, Immunohistochemistry, In Vivo, In Vitro, Cell Culture, Animal Models, Protein Chemistry, Confocal Microscopy, ELISA, Flow Cytometry, RT-PCR, Immunofluorescence, Fluorescence Microscopy, Cell Based Assays, qPCR, Multi-photon microscopy, Adeno-associated virus mediated gene delivery, stereotactic injections, Rodents surgery
Experience
Vice President of R&D
ReGeneLead--a subsidiary of Hengrui Pharma
Vice President of Discovery & Head of Gene Therapy
NeuShen Therapeutics US
Lexington, Massachusetts, United States
. Biology head for CNS drug discovery . BBB-penetrant novel AAV capsid discovery . miRNA-based gene therapy for ALS, Alzheimer's disease, Parkingson disease
Senior Director, Gene Therapy and Head of CNS Gene Therapy (Pre-clinical)
AGTC
Cambridge, MA
• Head of CNS gene therapy overseeing pre-clinical CNS discovery and development programs including ALS, AD, PD, FTD • Led a team and developed a trivalent construct incorporating gene silencing (miRNA) and gene augmentation elements in one construct to treat CNS disorders caused by both loss of function and gain of toxicity • Co-designed GLP non-human primate toxicity & biodistribution studies for AAV gene therapy programs (CNS and dry-AMD) • Co-led a cross-functional team and completed the pre-IND briefing package for a CNS AAV gene therapy program • Established a CNS scientific advisory board to support the CNS programs at AGTC • Pre-clinical support for the clinical ophthalmology programs including LXRP, ACHM A3/B3
Associate Principal Scientist
Merck
Greater Boston
. Neuroimmunology target identification and discovery for neurodegenerative diseases (ALS, PD, AD); . Small molecule-based drug discovery in neurodegenerative diseases (ALS, PD, AD); . Biomarker identification for neuroimmunology targets and neurodegenerative diseases; . Project lead and team lead
Senior Scientist III/Principal Scientist I
AbbVie
Cambridge, Massachusetts
. Neuroinflammation target identification and validation for Alzheimer's Disease . Microglia and microglia-like iPSC cell biology and potential targets for neurodegenerative diseases . Humanized and disease-relevant models and assay development
Assistant Professor of research in Neuroscience
Weill Cornell Medicine
New York, NY
. AAV gene therapy (AAV-APOE); . APOE biology and modulations for treating neurodegenerative diseases . AAV vectored antibody engineering and tau immunotherapy . Novel Alzheimer's disease animal models
Postdoctoral Scientist
Eli Lilly and Company
Indianapolis, Indiana Area
. APOE biology in Alzheimer's diseases; . Glia (microglia and astrocytes) and myeloid cells in Abeta clearance
Education
Harvard Medical School - Massachusetts General Hospital
Neurology
. Craniotomy and in vivo multi-photon microscopy . Vascular disorders in neurodegenerative diseases . Human tissue histology and imaging . Graduate Courses taken/audited: Immunology, Advanced Immunology, Molecular Genetics, Neuroimaging in CNS Diseases
Sun Yat-sen University
Neurobiology and Neurosciences
Lingzhi Zhao's Contact Information
Phone
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