Lindsay Kua

- Lead studies to solidify the company's allogeneic cell therapy platform through experimental validation of single cell sequencing findings indicating superior functionality and tumor tropism - Contribute to IND submission by assessing in vitro and in vivo activity of allogeneic cell therapy product

- Led a team of three scientists in evaluating in vitro and in vivo efficacy of candidate CAR T cell products - Spearheaded efforts to assess on-target off-tumor risk and to target the tumor microenvironment in contribution to the development of potential IND candidates - Drove single cell RNA and TCR sequencing project to gain a deeper understanding of the company’s allogeneic CAR EBVST product in collaboration with the Singapore Immunology Network - Contributed as co-author to 2 publications (1 published, 1 in press) - Prepared and authored technical disclosures as co-inventor of 2 patents

In the hope of uncovering new and better therapeutic interventions, I worked on efforts to dissect and understand the colorectal cancer tumor microenvironment using single cell sequencing and bulk transcriptomics approaches, coupled with in vitro culture of patient-derived cells intended to model tumor microenvironment interactions. - Planned, performed, and analyzed experiments to model the colorectal cancer tumor microenvironment - Streamlined experimental workflow for patient tumor-derived cells to ensure collection of integral data points - Analyzed bulk and single cell RNA sequencing data to discover possible correlates of patient prognosis and potential new therapeutic targets for in vitro validation - Managed scientific and budgetary aspects of a multi-million-dollar collaborative translational research and clinical trial study with a major multinational pharmaceutical industry partner - Contributed as co-author to 1 publication

Advisors: Christophe Benoist and Diane Mathis Dissertation: Intestinal symbionts in immune regulation and autoimmune disease

Immunology Group Advisor: Kong-Peng Lam

Advisor: Adele J. Wolfson Thesis: Regulation of thimet oligopeptidase by steroid hormones in the rodent brain.