Lijun Huang

Lead design and synthesis of novel ionizable and functionalized lipids for mRNA, siRNA, and gene-editing payload delivery. Directed cross-functional programs bridging chemistry, analytical, and formulation teams to enable preclinical and clinical LNP candidates. Managed CRO/CMO collaborations for GMP lipid production, ensuring quality, yield, and regulatory compliance. Pioneered incorporation of cleavable PEG lipids and targeted ligands to achieve extrahepatic delivery. Mentored and trained junior scientists in lipid synthesis, purification, and process optimization.

Led a customer synthesis team to deliver multiple high-purity (>97%) GalNAc conjugates and specialty phosphonamidites on time, from gram to multi-10-gram scale. Actively managed client communication through regular written and oral reports, ensuring transparency and addressing feedback throughout the project lifecycle. Directed the process development and scale-up of key oligonucleotide ingredients to multi-hundred-gram quantities. Took charge of troubleshooting complex quality issues, including the analysis and assignment of critical impurities to ensure robust processes. Pioneered research into novel liquid-phase synthesis techniques for complex nucleotides. Leveraged this expertise to support the Business Development team in introducing novel, practical know-how to clients and prospects. Represented the company's technical capabilities at scientific conferences and through direct client visits, effectively listening to and addressing client comments and concerns to strengthen relationships and identify new applications.

Designed and synthesized fragment-based libraries; optimized lead compounds to nanomolar potency via SAR studies. Applied process principles to scale multi-step heterocyclic syntheses efficiently for preclinical evaluation.