Laura Kowalczuk

High-Resolution Retinal Imaging | Translational Research Projects Fundraising, regulatory affairs, coordination, image analysis and statistics, scientific communications Key Projects: 2023 – Fondation Gelbert: Phenotyping inherited retinal diseases with innovative technologies for examining retinal function and structure (PHENOV: FAA Research Group Retinal Degeneration and Regeneration, FAA Oculogenetics department) 2022 – Innosuisse Innovation Project: Imaging retinal cells in degenerative diseases (IRIS: EPFL LAPD, FAA Retina Department, Earlysight SA)

High-Resolution Retinal Imaging | Translational Research | Clinical & Innovation Project Management Responsabilities & achievements: - Collaborated with academic (EPFL, INSERM UMRS1138), industrial (Earlysight SA), and clinical partners (FAA Retina Department and Clinical Investigation Center) - Participated to the development of high-resolution retinal imaging technology using oblique illumination: from experimental proof of concept to first-in-human clinical studies - Led project writing and fundraising (Innosuisse, EIT Health) - Managed clinical research projects (scientific, ethical, administrative aspects) - Performed biomedical image analysis and contributed to scientific dissemination (publications, conferences) Key Projects: 2022 – Innosuisse Innovation Project: Imaging retinal cells in degenerative diseases (IRIS) 2021 – Clinical Study ASSESS (NCT04398394) 2019–2020 – EIT Health: Retinal phase contrast imaging for early diagnosis (ASSESS) Key outcomes: Contributed to 6 publications, including 2 as first-author and 1 as last-author.

Coordination of regulatory, operational, and translational activities in clinical and research projects focused on high resolution imaging in retinal diseases. - Managed regulatory processes, study operations, data analysis, and dissemination of results for the ASSESS clinical study. - Led the setup of a translational research project focused on phenotyping patients with inherited retinal degeneration using innovative diagnostic methods.

Administrative, financial and regulatory management of research projects in ophthalmology - Co-managed the operations of the FAA's biobank - Supported the submission of the SOIN project to the Swiss Personalized Health Network (SPHN): finalized administrative and financial documentation. - Led the operational setup of an experimental high-resolution retinal camera (AO-SLO) and contributed to the review of its associated clinical protocol.

Coordination of translational research projects, focused on retinal vascular and edematous diseases. - Established a human tissue biobank: ethical submission, implementation of sample collection workflows, and setup of the data management system (SLims, Genohm / Agilent) - Coordinated a translational research network to identify biomarkers of vascular and edematous retinal diseases, using preclinical models and Omics analysis in human samples - Expanded the small animal imaging platform and used it in various collaborations (model characterization, drug delivery system development…) - Co-managed the administrative and financial aspects of an SNSF-funded project on the mineralocorticoid pathway in the retina. - Co-supervised Master’s students and MD research fellows. Key outcomes: Contributed to 11 publications, including 2 as first-author.

Coordination of translational research, focusing on drug delivery in ocular tissues - Coordinated "Innovision", a public-private research project (ANR RPIB) focused on the development of innovative protein-based therapies in ophthalmology. - Investigated iontophoresis as a delivery method for photosensitizing agents in corneal cross-linking treatments.

Development of femtosecond laser technology for imaging and surgical applications in anterior ocular tissues: - Investigated corneal properties in diabetic patients using non-linear microscopy, in collaboration with the Laboratory for Optics and Biosciences (LOB, École Polytechnique – CNRS – INSERM; Dr. Marie-Claire Schanne-Klein). - Participated in the development of precision laser surgery techniques for the anterior segment of the eye and in the investigation of their optical properties."

Research on non-viral gene therapy for ocular diseases, with a focus on electrotransfer applications in inflammatory and angiogenic eye conditions. - Performed preclinical studies on the expression of anti-TNFα via electrotransfer in experimental models of uveitis. - Investigated the overexpression of Placental Growth Factor, a key molecule involved in retinal vascular pathologies.

Purification and characterization of the recombinant interleukin-7 (IL-7) Training to engineering project management

Paris - ENPC School of International Management Formation "Paristech Docteur pour l'entreprise" - ENPC MBA Business Managment, Enterpreneurship, Risk Assessment, Finance, Negociation, Marketing, Innovation

INA P-G (Institut National Agronomique Paris-Grignon)