Laura BRULLE-SOUMARE

1. Pre-clinical study management: Pharmacology and oncology studies - Provides scientific support, strategic advice and recommendations to clients in the conduct of research studies, - Elaboration of study protocols and verification that the protocol, including any changes, is approved and is in compliance with the appropriate SOPs, GLPs, and regulatory agency guidelines. - Coordination with business development, to evaluate proposals, evaluate feasibility, and provide recommendations to clients. - Revision of cost estimates to ensure that all protocol/amendment driven workscope specifications have been included in the price estimation. - Collection, analyze and interpretation of data, preparation of reports and submission to the client. - Management of the external communication (privileged interlocutors of the Sponsors) - Assessment of client interest and technical feasibility of new assays. 2. Team management - Head of formulation department at Xentech - Leading qualified research technicians (people management and operational management) 3. R&D project manager -Development of new PDX models -Coordination between R&D department and operational team

Coordination of all in vivo studies in collaboration with private partners. - Preclinical evaluation of new therapeutics on PDX models, by imaging and caliper measurements. - In vitro evaluation of test items on cellular models - Procedure, protocol and report redactions - Submission of projects to ethical committees - Mobilization of resources from different department and units.

Development of multimodal preclinical imaging strategies for in vivo evaluation of new anticancer drugs. - Development of orthotopic models (pancreas, colon, lung tumor models) - Evaluation of tumor growth and metastatic dissemination by bioluminescence, 2D radiography, (single photon emission computed tomography (SPECT) and computed tomography (CT)

CIFRE phD Thesis Pre-clinical study management (GLP): pharmacology and oncology - Elaboration of study protocols in accordance with the guidelines - Analysis and synthesis the results (reporting) - Standard operating procedure (SOP) redaction - Coordination between private company (CERB) and academia (CNRS, UPS44) for the realization of the projects.