Lan Hua
Director @ BeiGene
China
Beijing
Pharmaceuticals
-
Experience
Director
BeiGene
Beijing, China
CADD-AI Platform Head
Principal Investigator
Global Health Drug Discovery Institute
Senior Investigator
Global Health Drug Discovery Institute
Investigator
Global Health Drug Discovery Institute
Beijing, China
Section head of CADD platform
Research Associate
National Institute of Biological Sciences (NIBS), Beijing.
Beijing, China
Joint Postdoc Researcher
Global Blood Therapeutics
• Conducted structure-based drug discovery for treating sickle cell disease and other blood diseases in close collaboration with medicinal chemists in GBT. • Designed and modeled hundreds of anti-sickling compounds, many of which are potent in vitro; one of compounds GBT440 (Voxelotor) was approved by FDA in 2019 • Published two patents and one paper
Postdoctoral researcher
University of California, San Francisco
San Francisco Bay Area
• Developed a novel approach to protein structure refinement which is a very challenging problem in protein structure prediction for the practical uses such as structure-based drug discovery • Investigated how (de)acetylation modulates enzyme activity of mitochondrial HMGCS2 • Studied protein loop flexibility by hierarchical Monte Carlo sampling • Participated in model quality assessment of protein targets submitted to CASP8 and CASP9
Education
Columbia University
Computational chemistry
Lan Hua's Contact Information
Phone
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