Laert Serjani

Scientist, in vivo Pharmacology at Mariana Oncology, helping in advancing personalized medicine and radiopharmaceuticals.Hands-on in vivo animal models in support of cross-functionally with other R&D team members to drive in vivo initiatives.Collaborating with several dependencies within Mariana and with partners/CROs outside of the company. Designing,developing protocols and interpreting data for both in-house and outsourced DMPK studies Preparing and conducting DMPK studies in rodents Small animal handling, dosing of peptide therapies via various routes (e.g. intravenous, subcutaneous and intraperitoneal) in mice and rats Performing blood draws, necropsies and tissue collection in rodents for bioanalytical analysis Complying with appropriate Standard Operating Procedures (SOPs).

• Lead and designed complex in-vivo research studies in collaboration with cross-functional teams. • Conducted in-vivo compound screening studies in rodents using various dosing routes (PO, IV, SQ, IP, IM, ID). • Perform advanced surgical procedures, including catheterization of jugular vein, carotid artery, and femoral artery in rats. • Collected precise blood samples through various methods, such as cardiac puncture, jugular vein catheter, retro-orbital bleed, saphenous vein bleed, submandibular, sublingual, and tail bleeds. • Demonstrated proficiency in cerebrospinal fluid (CSF) collection in rats and mice, contributing to neuroscience and neuropharmacology research. • Overseed and implemented in vivo tumor xenograft studies, skillfully measuring tumor progression in mice. • Operated and managed advanced laboratory equipment, like the Culex automated blood collection system, for streamlined research processes. • Maintained meticulous records of study data to support analysis and reporting. • Mentored and guide junior researchers in laboratory techniques, dosing methods, and tissue retrieval. • Collaborated closely with research leaders in planning and executing pharmacokinetic and toxicology studies. • Facilitated the development and validation of novel animal models. • Fostered a culture of continuous learning and innovation within the research team. • Efficiently managed laboratory operations, including inventory and supplies ordering

Collaborated effectively within a clients, delivering exceptional results as part of a cohesive team. • Demonstrated adeptness in handling multiple animal models (mice, rats, rabbits, dogs, pigs, monkeys) and skillfully administered dosages via IV, PO, SC, IM, IP. • Conducted blood collection through cardiac puncture, jugular vein catheter, retro-orbital bleed, and saphenous vein bleed with meticulous precision. • Undertook comprehensive urine and feces collection, executed necropsies, and skillfully harvested organs. • Excelled in novel compound formulation, solubility testing, and problem-solving. • Conducted pharmacokinetic and toxicology studies with exceptional attention to detail. • Successfully managed laboratory operations, inventory, and supplies procurement. • Demonstrated leadership as the lead technician on several complex TK/PK studies, effectively coordinating dosing and serial blood collection.

Contributed to pre-clinical in-vivo experiments and discovery research, with a specific focus on PK/PD and anti-inflammatory therapeutics. • Meticulously prepared dosing solutions and experimental reagents. • Demonstrated versatility in administering dosages via IV, PO, SC, and IP in mice and rats. • Expertly conducted blood collection using various methods, both in-life and terminal, with a strong commitment to precision. • Carried out necropsies and skillfully collected specific rodent organs and tissues. • Proficiently processed tissues and blood components, ensuring accurate results. • Applied in-vivo surgical skills, including the precise implantation of sub-cutaneous osmotic pumps. • Played a pivotal role in recording, organizing, maintaining, and analyzing study data, facilitating short and long-term experiment planning in collaboration with team members and senior scientists.