Shweta Kothari

Chinook Therapeutics (Nasdaq: KDNY) is a clinical-stage biotechnology company developing precision medicines for kidney diseases. Chinook’s product candidates are being investigated in rare, severe chronic kidney disorders with opportunities for well-defined clinical pathways.

Understanding the pathophysiology of ischemic stroke using spectroscopic, biophysical and cell biology approaches. Focused on the role of thrombin mediating cytotoxicity and cytoprotection in the brain. Establishment of Preclinical models of therapeutic hypothermia. Design and execution of In-vitro experiments to study cerebrovascular ischemia and traumatic brain injury in neurovascular unit. Assist in development of transgenic mouse models for selectively targeting different cell of neurovascular unit. Management and characterization of transgenic mouse models. Administrative duties to maintain the workings of the laboratory. Conducted biochemical, molecular biological, imaging, and behavioral research. Optimized and align breeding according progress of research projects. Additionally responsible for executing PCR assay protocols and performing genetic assessments.

Preclinical and translational research on stroke therapy using in-vitro models, lentivirus and knockout mouse models. Preclinical studies for novel pharmacological compounds for stroke therapy. • Optimizing PCR and genotyping protocols for multiple transgenic mice lines. • Executing In-vitro experiments to study cerebrovascular ischemia and traumatic brain injury. • laboratory organization and compliance with health and safety guidelines. • Gather, analyze and randomize data for publications, presentations and scholarly meetings • Liaise with vendors, company representatives etc. • Recipient of Care -Share award (2015) in recognition of excellence

Research focus - Investigating the role of apolipoprotein E (apoE) in cholesterol metabolism and its relation to cardiovascular disease from a biochemical and biophysical perspective. Teaching associate and Lab instructor a for General Chemistry, Department of Chemistry and Biochemistry, CSULB AIC (Grad) Biochemistry and Outstanding Thesis awards Recipient of CSU annual biotechnology symposium travel grant Recipient of McAbee-Overstreet Graduate Research Scholarship for excellence in commitment to research in chemistry or biochemistry, CSULB Recipient of Biophysical Society’s travel award