Kaizhu Guo

Associate Principal Scientist @ Merck

About

Specialized in analytical method development for single vesicle analysis, biomarker detection and bioconjugation.

Country

United States

City

Rahway

Industry

Chemicals

Skill

Flow Cytometry, Confocal Microscopy, Atomic Force Microscope, Liquid Chromatography-Mass Spectrometry (LC-MS), HPLC, Polymerase Chain Reaction (PCR), Western Blotting, ELISA, UV/Vis Spectroscopy, Gel Electrophoresis, GC-MS, GC-FID, Nanoparticle Tracking Analysis, ICP-OES, E-beam Evaporation

Experience

Associate Principal Scientist

Merck

2025-6 - Present · 1 yr 4 mos

United States

Senior Scientist

Merck

2021-8 - 2025-5 · 3 yrs 10 mos

Kenilworth, New Jersey, United States

Biologics Analytical R&D

Graduate Student Researcher

University of California, Riverside

2016-9 - 2021-7 · 4 yrs 11 mos

Riverside, California, United States

• Designed and constructed various DNA nanostructure for single extracellular vesicle analysis. • Established methodology for quantitative/quantitative proteomics to quantify and compare the protein expression level in extracellular vesicle derived from various cell lines. • Monitored EV secretion and the enclosed miRNA cargos in cell culture medium.

Research Assistant

Southern University of Science and Technology

2013-9 - 2016-6 · 2 yrs 10 mos

Shenzhen, Guangdong, China

• Developed a magnetic bead-based integrated method for proteomic analysis and applied it to identify 218 proteins in serum using HPLC-MS. • Redesigned and simplified the conventional experimental operation by integrating protein preconcentration, reduction, alkylation and digestion into a single tube.