Jyoti Baranwal, PhD
Postdoctoral Researcher @ Columbia University
About
Largely, in my research career, I have accompanied multiple projects on a variety of proteins, i.e., Ras-like GTPases, Kinases and membrane proteins. Utilized structural biology as a tool and used biochemical methods to understand the molecular mechanisms of several proteins. As a Structural Biologist with six years of experience in Cryo-Electron Microscopy (Cryo-EM), X-ray Crystallography, and, I specialize in understanding the molecular mechanisms underlying protein function. My expertise in protein-protein interactions, and drug discovery has led to successful collaborations in both academic and industry settings. I am proficient in data analysis tools such as cryoSPARC and Phenix, and I am passionate about contributing to cutting-edge research that advances therapeutic solutions. Looking forward to applying my skills to a role that combines structural biology, biophysics, and drug development.
United States
New York
Biotechnology
Cell Culture, X-ray crystallography, CryoEM, Assay Development, Western Blotting, SDS-PAGE, Protein Crystallization, E. coli, Isothermal Titration Calorimetry, Refeyn Mass Photometry, SEC-MALS, Baculovirus mediated protein expression, Liposome preparation, TEM, Dynamic Light Scattering (DLS), Fluorescence Microscopy, Insect cell culture, Mammalian Cell Culture, Protein Expression, Biochemistry
Experience

Postdoctoral Researcher
Greehey Children Cancer Research Institute The University of Texas Health Science Center San Antonio
San Antonio, Texas, United States

Ph.D.
India
During my Ph.D., I have discovered a novel interaction of MglB C-terminal helix to an allosteric site of MglA, a GTPase which regulates the cell polarity and motility in M. xanthus. We discovered that MglB is a unique protein found amongst all the regulator of small Ras-like GTPase family of proteins which can act as a GAP (GTPase activating protein) and GEF (Guanine nucleotide exchange factor), for the same GTPase MglA.
Education
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