Junhua Qiao

EVP and Head of CMC @ I-Mab Biopharma

About

PhD scientist with proven scientific tracking on molecule biology, gene regulation and gene targeting, cell line development, cell culture and process development, , tech transfer and CMC management Deep knowledge of therapeutic protein development: from drug discovery, process development, cGMP manufacturing to US/China IND filing Profound CMC project management: including budget, timeline, deliverable, communication and risk management Business development experience for biologics development, strong business-orientated mindset for CDMO service Familiar with the landscape of Biologics development in China Leadership experience of multiple interdisciplinary team management Broad connections in academia, both in China and in Europe

Country

China

City

Pudong

Industry

Biotechnology

Skill

Cell

Experience

EVP and Head of CMC

I-Mab Biopharma

2017-8 - Present · 9 yrs 2 mos

Shanghai City, China

Late stage process development, Process Characterization, Process Validation, Due diligence, global and domestic CDMO sourcing and management, budget management,

Director, Head of Biologics Development

Hansoh BioMedical R&D Inc./Hansoh Pharmaceutical Group 豪森药业集团

2016-8 - 2017-7 · 1 yr

Shanghai City, China

in licensing project evaluation, Biologics portfolio management, CMC outsource management, project managment, Biologics in house capability development

Director

WuXi AppTec

2012-4 - 2016-7 · 4 yrs 4 mos

Shanghai

Develop CHO-K1 stable cell line platform, from host cell adaptation, host clone screening, stable cell line development and process development, titer above 4g/L Develop CHO-K1 transient expression platform, scale from 1L to 50L, titer range 50--500 mg/L for mAb, enzyme and recombinant proteins Generate fast stable pool and stable cell line by targeted integration technology, reduce the timeline from DNA to stable pool to 3 weeks and stable cell lines to 8 weeks Act as CMC leader for a novel enzyme porject, from cell line development, upstream and downstream development, analytical methods development and GMP production for IND enabling in US Act as CMC leader for a key account client for research material generation by transient expression in mammalian cells Manage a group of 20 scientists covering variable cell line development functions, such as molecule biology, cell line development, new technology development, research material generation by transient technology and cell line testing, etc. Write government grant application, patent application, etc

Research Scientist

Boehringer Ingelheim

2011 - 2012 · 1 yr

Biberach, Germany

Group of Molecule Biology Process Science, Germany Next generation of cell line development by targted integration technology Industrial cell line development by using viral infection technology

Postdoc

University of Lausanne - UNIL

2009-8 - 2011-5 · 1 yr 10 mos

Investigate the funciton of MAR elements on transcription initiation in live cells by using single cell imaging technology

PhD candidate in Molecular Biology

Helmholtz Centre for Infection Research (former GBF)

2005-11 - 2009-8 · 3 yrs 10 mos

PhD candidate Helmholtz-Zentrum für Infektionsforschung (HZI), Braunschweig/Germany Coordinated a cell line development project with industrial partner (InVivo Biotech Services, Berlin); routinely reported to CSO of InVivo, oral and written Developed a novel method to generate cell lines with stable and predictable transgene-expression properties in a timeline-efficient, cost-effective and high-throughput manner Supervised Master student for practical courses and thesis researches Embedded in other project teams, providing scientific advices and/or technical supports

Intern

BASF

2004-1 - 2004-5 · 5 mos

Participated in a project to synthesize and characterize new superplasticizers with anticorrosion function Delivered the product from lab scale to pilot plant

Management Trainee

Carrier China Corporation

2001-7 - 2002-9 · 1 yr 3 mos

Rotation training within different sub-companies of Carrier China Corporation Implemented projects in marketing analysis, dealer management, quality and cost control with other trainees