Josquin Nys

• Provide scientific rationale for building an immunology and inflammatory pipeline. • Work with the executive leadership team to shape the strategic R&D direction • Design, contract, and oversee immunological studies supporting drug discovery and nonclinical development of Windward Bio’s pipeline • Collaborate with nonclinical development, clinical development, regulatory affairs, and manufacturing, to ensure the smooth progression of immunology-related drug candidates through the pipeline.

Project leader for mucosal immunology pre-clinical targets for IBD and asthma • Provide project strategic direction and timelines • Responsible for the pharmacology and pre-clinical biology strategy of the projects (in vitro and in vivo biology) • Involved in new target selection • Represent the project team for interactions with stakeholders and governance • Work in a matrix, interacting with Protein Engineering, CMC, DMPK, Tox and IP departments. Interactions are cross-disease areas and cross-sites People management and development • Manage five scientists and one technician & co-supervise two PhD students • Lead, develop and organize all activities of the team

Project leader for mucosal immunology pre-clinical targets for IBD and asthma • Provide project strategic direction and timelines • Responsible for the pharmacology and pre-clinical biology strategy of the projects (in vitro and in vivo biology) • Involved in new target selection • Represent the project team for interactions with stakeholders and governance • Work in a matrix, interacting with Protein Engineering, CMC, DMPK, Tox and IP departments. Interactions are cross-disease areas and cross-sites People management and development • Manage four scientists and one technician & co-supervise three PhD students • Lead, develop and organize all activities of the team

Project leader for an IBD pre-clinical target • Establish project strategic direction and scientific support to the project • Develop and implement the pharmacology as well as pre-clinical biology work • Represent the team for interactions with stakeholders and governance • Team leader (one scientist, one technician ) • Manage external academic collaborations and PhD students

• Develop novel assays and cellular models to test anti-inflammatory molecules in COPD • Establish, validate and perform in vitro assays to support translational work • Submit target proposals • Contribute to department research strategies within task force • Generate scientific presentations and reports for internal review meetings

Impact of Atacicept on macrophages and dendritic cells. Investigating the potential reverse signalling through BAFF and APRIL.

Analysis of the role of the kinase Syk in mature B cells using a mouse inducible KO Cre system. I performed in-vivo and ex-vivo studies and demonstrated the role of Syk in mature and memory B cell.