Joachim Wahl

• Appointed member of a governmental ethics committee reviewing animal research proposals in accordance with the German Animal Welfare Act • Provide scientific and ethical evaluation of study designs, including regulatory compliance and risk–benefit assessments • Contribute to informed decision-making in the approval of preclinical research programs

• Led in vivo pharmacology and vivarium operations supporting global oncology programs in a regulated research environment • Directed the design and execution of preclinical studies (efficacy, safety, pharmacokinetics), contributing to regulatory submissions and clinical trial applications • Managed and developed interdisciplinary teams, driving scientific excellence, training, and reliable study delivery • Contributed to nonclinical development strategies and cross-functional alignment, supporting decision-making in complex programs • Led AAALAC accreditation and compliance initiatives, ensuring high standards in animal welfare and regulatory adherence • Supported investment planning through business case development and implementation of major equipment and infrastructure • Co-inventor on multiple patents related to bispecific antibody (BiTE) therapies Joined Micromet prior to its acquisition by Amgen and contributed to the continued development of BiTE programs within the integrated organization.

Led comprehensive research on pediatric neuroectodermal tumors, exploring tumor-origin and stem cells within the 'Tumor Stem Cells' association funded by the German Cancer Aid. Collaborated extensively in pediatric tumor research, cultivating expertise in tumor biology and stem cell techniques. Mentored scientists, resulting in publications on tumor stem cells and pioneered viral/genetic therapeutic approaches. Establishing orthotopic mouse models for Ewing's sarcoma, neuroblastoma, and glioblastoma.

Achieved the completion of the PhD thesis, 'Molecular and Functional Characterization of the Tetraspanin D6.1A,' in the Department of Tumor Progression at the German Cancer Research Centre, earning a magna cum laude degree from the University of Heidelberg.

Established tumor and angiogenesis models, conducted experimental treatments, planned and analyzed experiments, and mentored apprentices and interns of the local university.

Successful completion of the 3-year vocational training as a biological laboratory technician with focus on pharmacology, microbiology and histology at Boehringer Ingelheim (Dr. Karl Thomae GmbH) in Biberach. Utilized advanced molecular biology techniques to assess nucleic acids in biotechnological samples crucial for batch clearance, while spearheading the development of a new analytical method for routine implementation.

Attained an extra-occupational M.Sc. in Laboratory Animal Sciences, culminating in a successful thesis on the systematic review and meta-analysis of obesity's effects on stroke outcome in animal models of ischemic stroke, earning a FELASA certificate as expert in Laboratory Animal Sciences (category D).