Jingdong Ye

Principal Scientist, Biotechnology, Discovery Chemistry @ Arrowhead Pharmaceuticals

Country

United States

City

Madison

Industry

Pharmaceuticals

Skill

University Teaching, Science, Phage Display, Higher Education, Biochemistry, Lecturing, Statistics, Molecular Biology, Cell Biology, Cell Culture, Life Sciences, Protein Expression, Protein Purification, UV/Vis Spectroscopy, High-Performance Liquid Chromatography (HPLC), Gas Chromatography, Protein Chemistry, Polymerase Chain Reaction (PCR)

Experience

Principal Scientist, Biotechnology, Discovery Chemistry

Arrowhead Pharmaceuticals

2025-4 - Present · 1 yr 6 mos

Madison, Wisconsin, United States

Senior Scientist III, Discovery Chemistry

Arrowhead Pharmaceuticals

2022-8 - 2025-4 · 2 yrs 9 mos

Madison, Wisconsin, United States

Antibody Oligonucleotide Conjugates (AOC) for next generation siRNA delivery

Director, Antibody Discovery Technologies

SPARX BIOPHARMACEUTICAL CORP

2018-10 - 2022-8 · 3 yrs 11 mos

Mount Prospect, IL

• Humanization, affinity maturation of Fabs, scFvs and nanobodies through antibody phage display. Synthetic naïve antibody library construction and selection Antibody koff selection Tumor specific pH antibody library construction and selection Novel bispecific antibody platform design Optimization of stability and expression of multi-domain (over 6 domains) bispecific antibody platform through antibody phage display • Method development and validation of critical quality attributes of antibody drugs: impurities and aggregates (SE-HPLC, HIC), charge separation (CEX), process related impurities (Host Cell Proteins, Residual Protein A), potency (ELISA, ADCC).

Metrology Specialist and Formulation chemist

SGS

2015-12 - 2018-9 · 2 yrs 10 mos

Greater Chicago Area

Expertise in preventive maintenance, performance verification, general repair and troubleshooting in Agilent HPLC, Waters HPLC, Agilent GC, Acquity classic UPLC, Acquity UPLC H-class, Discovery DSC, and TGA Q500. Expertise in pharmaceutical sample testing on XRPD, dissolution apparatus, HPLC, and UV/VIS.