Jennifer Cockerill

Monitored studies at contract research organizations (CROs), ensuring compliance with protocols, timelines, and quality standards. Served as primary point of contact for clients, providing updates on project progress, experimental design, and scientific results. Implemented project tracking systems and reporting metrics to improve visibility and decision-making across all programs. Supported assay development, study design, and experimental planning, integrating scientific workflows with project management processes. Facilitated cross-functional collaboration between internal teams and client stakeholders to mitigate risks and solve complex research challenges.

Conducted non-GLP preclinical toxicology and pharmacokinetic studies, managing all aspects from protocol development and in-life procedures through data analysis and reporting. Designed and executed toxicology studies for the cross-functional peripheral neuropathy working group, contributing to translational and therapeutic decision-making. Managed study setup and data collection using Xybion Pristima software, ensuring accurate and compliant reporting. Trained and mentored new hires on technical animal procedures, study conduct, and laboratory best practices. Maintained continuity of all responsibilities previously held at Seagen Inc. while integrating into Pfizer’s global research processes.

Executed in-life rodent studies, including IV/i.p./s.c. dosing, intravesical administration, blood collection, anesthesia, necropsy, tissue collection, body weight monitoring, and clinical observations in compliance with IACUC protocols. Designed and performed in vitro neurite outgrowth assays to assess neuronal toxicity of ADCs and correlate findings with peripheral neuropathy observed in clinical studies. Conducted colony-forming unit (CFU) assays with ADCs in human, non-human primate, and rat hematopoietic stem cells to evaluate potential bone marrow toxicity. Performed in vivo imaging of rodents using the Perkin-Elmer IVIS system to monitor therapeutic distribution and preclinical efficacy.

Oversaw preclinical studies at CROs, managing study execution, monitoring adherence to protocols, and ensuring timely and accurate data delivery. Contributed to preclinical study design and presented findings to cross-functional teams, including Life Sciences, Engineering, and leadership stakeholders. Developed and implemented devices for nasal dosing of liquid and powder test articles in rodents, performing hands-on dosing as needed. Trained CRO animal technicians on proper use of proprietary nasal dosing devices and monitored study conduct to ensure consistency and compliance. Conducted non-compartmental pharmacokinetic analysis of preclinical data using Phoenix WinNonlin to support therapeutic development decisions.

Developed and tested color-matched placebo powders for clinical trials, delivering solutions promptly and cost-effectively. Performed formulation-device compatibility testing and USP <731> Loss on Drying analysis to ensure product quality. Collaborated on method development and conducted device testing using HPLC, Karl Fischer Titration, tapped density, and Cascade Impaction. Executed rodent procedures, including anesthesia, intranasal dosing, euthanasia, and dissection, supporting in vivo study objectives. Assisted with protocol planning and supervised the execution of pharmacokinetic and toxicology studies in primates and rodents. Trained technicians on proper intranasal dosing techniques in both rodents and primates. Maintained organized laboratory notebooks and IACUC documentation, ensuring compliance and reproducibility. Implemented and promoted laboratory safety procedures as an active member of the safety committee.