Jaykumar Barot

* Provide strategic leadership for upstream development of mammalian expression systems, driving CDMO programs from clone selection to early clinical GMP manufacturing. * Build and mentor a high‑performing technical team, fostering scientific excellence, accountability, and continuous improvement. *Champion best practices, ensure cross‑functional alignment, and resolve inter‑departmental challenges through data‑driven decision‑making. Ensure strict adherence to project plans, timelines, and scientific standards. * Lead compliance with GMP upstream procedures, quality systems, and documentation. Oversee internal, client, and regulatory audits, ensuring readiness and robust closure of observations. Maintain highest EHS standards across lab, pilot, and manufacturing operations. * Collaborate with cell line engineering teams during clone development and oversee seamless transfer of clones into process development. Direct creation of GMP‑compliant cell banks supporting early clinical programs. * Design and optimize robust fed‑batch and perfusion processes, ensuring scalability and reproducibility. Drive adoption of advanced technologies to enhance productivity and enable continuous manufacturing. Apply statistical tools to evaluate process performance and consistency. * Oversee operation and maintenance of bioreactors across scales (Ambr 15, Ambr 250, 5 L, 50 L, 200 L) and ensure effective use of automation and control software. * Lead upstream‑to‑downstream tech transfer and support costing of development and GMP manufacturing activities. Author and review technical reports, cell line and cell banking documentation, and regulatory submission sections for IND‑enabling studies. Perform additional responsibilities as assigned.

-Lead scientific initiatives to support sales and application teams in Upstream Bioprocessing, enhancing the Cell Culture Media offerings. -Collaborate closely with product development teams to innovate solutions that align with market demands, ensuring product excellence. -Conduct comprehensive market research and engage with key opinion leaders to anticipate and stay ahead of biopharmaceutical trends. -Drive strategic initiatives to improve product performance and customer satisfaction in the Cell Culture Media portfolio. -Foster cross-functional collaboration to streamline processes and enhance product development efficiency. -Utilize data-driven insights to inform decision-making and optimize product strategies. -Champion continuous improvement and innovation within the Cell Culture Media portfolio to maintain competitive advantage.

• Managed a diverse portfolio of cell culture media and cell line development services at Sartorius. • Led a team of Product Specialists to provide technical support across Asia, enhancing regional sales efforts. • Developed and executed tactical plans for product promotion, resulting in improved market penetration. • Acted as the primary contact for application and quality escalations, ensuring customer satisfaction and product integrity.

Scientist and team leader of Up-stream process technology transfer and acting SME for manufacturing technical support. Involved in process development for Bio similars in Microbial and Mammalian cell culture platforms. Screening of media, feed and additives for achieving desired product quality with high titers. Experienced in preparation of cell bank with complete cGMP compliant documents.

Upstream Process development and scale up from Lab scale Bioreactor to Pilot scale Bioreactor. Execution of process consistency batches for readiness of technology transfer.Prepare technology transfer document package. Manage Pilot plant for audit readiness.

Small scale development of upstream process for Biotherpeutics and Biosimilars. Process optimization for achieving desired product quality and titer. Sacle up of the upstream process from 2 L scale to 200 L scale Bioreactor. Prepare Process development report for Upstream process.