Jake Fathman
Associate Director Pharmacology @ Neomorph, Inc.
About
• 15+ years experience in the study of in vitro and in vivo murine models of human disease. • My personal and career goals are to lead a team that works towards improving the understanding and treatment of human diseases. I am particularly interested in the biological mechanisms underlying cancer and autoimmunity as well as the development of therapeutics for the treatment of such diseases. • Great oral/written communication skills, creative problem-solving and multitasking, works well in collaborative teams, ability to integrate detailed analysis into a larger disease-oriented context.
United States
San Diego
Biotechnology
Multi-parameter flow-cytometry, in vitro cell biology, in vivo cell transplantations, In Vivo, Cell Biology, Immunology, Cell Culture, In Vitro, Cell, Stem Cells, Developmental Biology, Flow Cytometry, Drug Discovery, FACS, Genetics, Mouse Models, recombinant DNA technology, Molecular Biology, Immunoassays, Pharmacology
Experience
Associate Director Pharmacology
Neomorph, Inc.
Principal Scientist
Neomorph, Inc.
San Diego County, California, United States
Pharmacology
Principal Scientist II
GNF
Investigator III
GNF
La Jolla, CA
Investigator II
GNF
La Jolla, CA
Department of Cancer Therapeutics
Institute Fellow
GNF
La Jolla, CA
Postdoctoral Fellow
GNF
La Jolla, CA
Drug Discovery, In Vivo Pharmacology My postdoctoral research entails developing, optimizing and running high throughput screens on primary human and mouse immune cells to identify novel tumor immunotherapy and autoimmune targets. To this end, I utilize high throughput flow cytometry, high content imaging, and mass cytometry (CYTOF) to characterize immune responses to perturbations with small molecules, biologics, or genomic manipulation. I also work on late-stage projects by developing cellular and in vivo assays to aid in the validation and efficacy of compounds and biologics to specific targets.
Immunology Graduate Student
Stanford University School of Medicine
Dr. Irv Weissman's Lab, Stanford Stem Cell Institute
My doctoral work drew upon areas of immunology, developmental biology and stem cell research to address questions regarding Natural Killer cell (NK) development. I studied the different developmental stages and the transcription factors that allow a hematopoietic stem cell to differentiate into a mature and functional NK cell. I also identified novel cell surface markers on murine and human hematopoietic stem cells with the use of 12-color flow cytometry and microarrays, which allows for the rapid purification of highly enriched populations.
Research Assistant III
Scripps Research
Dr. Kerri Mowen's Lab, Immunology
Studied the role of arginine methylation and NIP45 deficient mast cells in the context of parasite infection and rheumatoid arthritis. I accompanied Dr. Mowen from Boston to help her establish her new lab at TSRI.
Research Assistant
Harvard Medical School
Dr. Laurie Glimcher's Immunology
Researched the role of T-bet in multiple murine models of rheumatoid arthritis and scleroderma. Characterized lymphocyte phenotypes of NIP45 deficient mice.
Education
Stanford University School of Medicine
Immunology
Lewis & Clark College
Biology
Jake Fathman's Contact Information
Phone
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