Isaac Knudson
Scientist @ Calico Life Sciences
About
Chemist/chemical biologist experienced in peptide chemistry, noncannonical amino acids, and genetic code expansion.
United States
Berkeley
Higher Education
Purification, Medicinal Chemistry, Oligonucleotides, Bioconjugation, Oligonucleotide Purification, Oligonucleotide Analysis, Teamwork, Protein Expression, Cell Culture, Electrophoretic Mobility Shift Assay (EMSA), Polymer Chemistry, In Vitro Translation, Peptide Chemistry, Genetic Code Expansion, Organic Chemistry, Pedagogy, Lamguir Trough Nanosheet Synthesis and Deposition, Microscopy, Confocal Microscopy, ImageJ
Experience
Scientist
Calico Life Sciences
South San Francisco, California, United States
Group Leader of Peptide Chemistry Co-built peptide chemistry lab Peptide drug designer Lead chemist in Calico’s ML/AI molecular design platform
Postdoctoral Researcher
University of California, Berkeley
Developing macrocyclization chemistry for peptide therapeutics with an emphasis on novel forms of conformational control and compatibility with genetically encoded libraries.
Graduate Student Researcher
University of California, Berkeley
PhD in the Schepartz lab as a member of the NSF Center for Genetically Encoded Materials (CGEM). Synthesis of noncanonical monomers for use in genetic code expansion. Exploring the scope of ribosomal catalysis with alternative electrophiles and nucleophiles. Developing novel cyclization chemistry for peptide macrocycle therapeutics.
Graduate Student Instructor
University of California, Berkeley
Berkeley, California, United States
Graduate student instructor for the Graduate-level Chemical Biology class, taught by Prof. Alanna Schepartz and Prof. Michael Marletta. I helped to coordinate and solicit materials for 12 lectures delivered by renowned faculty (3+ Nobel Laureates). I wrote and graded problem sets and exams for the course.
Graduate Student Instructor
University of California, Berkeley
Berkeley, California, United States
Instructor for Organic Chemistry Lecture and Lab (CHEM 3A/L). Planned lessons and delivered prelab lectures, while holding office hours and grading PSets and exams.
Graduate Student/Postdoc
NSF Center for Genetically Encoded Materials
Berkeley, California, United States
Post-Bac Researcher
Berkeley Lab
Berkeley, California, United States
Synthesized and tested mannose-functionalized peptoid nanosheets for bacterial capture-and-kill applications under the guidance of Ron Zuckermann at the Molecular Foundry.
Undergraduate Researcher
Columbia University
New York, New York, United States
Campos Lab, Department of Chemistry. Synthesized charge-delocalized aromatic polyelectrolytes as potential materials for ion exchange membranes in batteries.
Undergraduate Researcher
University of Florida
Gainesville, Florida, United States
Bungert Lab, Department of Biochemistry and Molecular Biology. Expressed, characterized, and delivered synthetic zinc-finger DNA-binding domains to mammalian cells.
Education
University of California, Berkeley, College of Chemistry
Chemical Biology
Columbia University
Chemistry
Cum Laude, Thomas J. Katz Award, Societe de Chimie Industrielle Fellowship
University of Florida
Chemistry
Phi Beta Kappa, Presidential Gold Scholar, Honors Program
Isaac Knudson's Contact Information
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