Inga Jarmoskaite

- Bioanalytical lead for preclinical development of ADAR-recruiting antisense oligonucleotides. - Manage an in-house bioanalytical team. - Oversee bioanalytical method development and validation by external CROs. - Author technical reports and contribute to preclinical sections of regulatory documents.

Prof. Jin Billy Li's group - Identified principles for sequence optimization of antisense guides used in site-directed RNA editing - Demonstrated POC of site-directed RNA editing in several preclinical disease models

Prof. Daniel Herschlag's group (2014–2019): - Developed a predictive model for RNA binding by human Pumilio proteins based on tens of thousands of quantitative binding measurements. - Co-developed a theoretical framework for RNAi and CRISPR specificity. - Tested nearest-neighbor RNA structure predictions in thousands of RNA constructs, revealing systematic errors in current algorithms. - Co-developed a predictive model for RNA structure-mediated cooperativity of RNA/protein interactions. - Devised guidelines for accurate thermodynamic and kinetic measurements of protein/nucleic-acid interactions. Prof. Jin Billy Li's group (2019–2020): - Developed a high-throughput screening platform for ADAR-mediated RNA editing.

Faculty advisor: Dr. Rick Russell - Performed quantitative mechanistic studies of RNA structural remodeling by a DEAD-box RNA helicase. - Revealed enhancement of DEAD-box RNA chaperone activity by exposed RNA helices and reduced compactness of RNA structure. - Demonstrated consumption of hundreds of ATP molecules during chaperone-mediated refolding of a misfolded ribozyme, revealing a non-specific, energy-intensive mechanism.