Indranil Mukhopadhyay

Drug discovery professional @ Revio Therapeutics

About

Seasoned drug discovery expert with 20+ years of pre-clinical research experience, consistently driving innovation and delivering breakthrough therapies across multiple therapeutic areas. Experience spans both academic and industry settings, with deep expertise in pharmacology, cell biology, signal transduction, and immunology. Proven track record in leading discovery biology research, particularly in inflammation, pain, fibrosis, dermatology, and oncology. Demonstrated scientific and technical acumen in drug discovery, with proficiency in target identification, assay development, optimization, and screening. Successfully led multiple cross-functional project teams from inception through to development candidate selection, ensuring the seamless translation of research into clinical potential. Led strategic planning and business development, contributing to the creation of a robust product pipeline from discovery to early-stage clinical development. Driven by a passion for advancing human health, always eager to push the boundaries of drug discovery and development. Key accomplishments/Milestones: # Lead preclinical characterization of 3 clinical candidates (GRC 17536; Phase 2a, GRC15300 & INS018_055; Phase 1) # Successfully accomplished clinical candidate identification of 6 NCEs within 1-3 years of project inception # Established Hsp70 as an early biomarker of cellular damage # Established single cell gel electrophoresis in Drosophila tissues Core competencies: # Drug discovery # Strategy planning & execution # Startup operations # Project management # Preclinical research # Pharmacology # Cell biology # Assay development and validation # Lead optimization # Mechanism of action # Hit-to-lead # Translational research # Biomarker research # Target identification and validation # Cellular and biochemical assays # Ex-vivo assays # In vivo models # CRO management

Country

City

India

Industry

Pharmaceuticals

Skill

Preclinical drug discovery, Drug Discovery, Pre-clinical, Leadership, Project Management, Team Management, Innovation, Strategy, Business Development, Collaboration, CRO Management, Analytical Skills, Assay Development, Interdisciplinary Collaboration, Cell Biology

Experience

Head, Preclinical Development

Revio Therapeutics

2025-3 - Present · 1 yr 7 mos

Hyderabad, Telangana, India

Assistant Vice President, Drug Discovery Biology

Enveda

2022-12 - 2024-8 · 1 yr 9 mos

Hyderabad, Telangana, India

# Led in vitro and in vivo research efforts towards discovery of natural product-derived bioactive compounds # Led and mentored teams to establish and implement translatable critical path processes such as in-vitro and in-vivo testing, experimental designs, disease relevant biomarkers, and disease-relevant end-points # Mentored project teams regarding standard drug discovery process including assay validation, generation of study reports, support regulatory filings, and planning for early clinical development # Worked towards improvising the traditional route of pre-clinical drug discovery through novel, innovative ideas and approach # Guided both the project and leadership teams with timely and clear decisions/recommendations

Director, Drug Discovery Biology

Enveda

2021-7 - 2022-12 · 1 yr 6 mos

India

Head, Translational Pharmacology

Insilico Medicine

2020-8 - 2021-7 · 1 yr

# Contributed towards discovery and pre-clinical development strategy and execution of development plans # Collaborated with CROs and external academic institutions for in vitro, in vivo pharmacology and translational research studies # Provided in vitro/in vivo pharmacology and translational research strategy for more than 12 discovery programs in therapeutic areas of fibrosis, metabolic diseases and oncology # Provided strong scientific, technical, and organizational leadership towards target ID # Worked closely with CROs to develop pre-clinical packages for IND submissions, including study design, monitoring, data analysis, interpretation and reports fit for regulatory submission # Contributed towards drafting pre-clinical data package for drug candidate nomination

Head, Preclinical Pharmacology

Insilico Medicine

2020-1 - 2020-7 · 7 mos

Senior Principal Scientist (DGM)

Glenmark Pharmaceuticals

2015-1 - 2019-12 · 5 yrs

Navi Mumbai

# Planned research strategies and execution of projects; performed root cause analysis # Monitored & analyzed progress, troubleshoot & interpret results # Designed, developed and carried out cellular & biochemical in vitro assays for screening & profiling NCEs # Managed establishment & execution of ex vivo & in vitro translational studies # Worked extensively towards developing Centre of Excellence for biophysical screening (SPR, TSA) # Provided guidance and mentorship to the team to develop specialized assays and to drive discovery programs # Competitive intelligence and keeping up to date with the developments # Published research articles in pharmaceutical journals

Principal Scientist

Glenmark Pharmaceuticals

2009-4 - 2014-12 · 5 yrs 9 mos

Navi Mumbai

Senior Scientist

Glenmark Pharmaceuticals

2007-7 - 2009-3 · 1 yr 9 mos

Postdoctoral Fellow

National Institute of Allergy & Infectious Diseases, NIH

2006-2 - 2007-6 · 1 yr 5 mos

Rockville MD, USA

# Functionally characterized RGS proteins in normal and disease states of asthma.

Postdoctoral Fellow

National Cancer Institute (NCI)

2004-6 - 2006-1 · 1 yr 8 mos

Rockville, MD, USA

# Seminal work on establishing novel molecular mechanism of Adaphostin (protein tyrosine kinase inhibitor).

Postdoctoral Fellow

University of Massachusetts Medical School

2003-9 - 2004-5 · 9 mos

Worcester, MA, USA

Senior Research Fellow

Indian Institute of Toxicological Research

1999-12 - 2003-8 · 3 yrs 9 mos

Lucknow, India

Education

Indian Institute of Toxicology Research

Zoology

1999 - 2003 · 4 yrs

# Worked on environmental chemicals as part of doctoral program to investigate the potential of heat shock protein 70 as an early biomarker of cellular damage. # Seminal work on establishing single Comet assay in Drosophila tissues.