Hubert Geisler

Minos Biosciences is on the path to bridge molecular and cell biology in a manner never achieved before that will, in turn, allow scientists to uncover the full picture of cell diversity and dynamics. By combining multi-omics analysis with phenotypic analysis at cell resolution and at high throughput, Minos’ solution provides a new paradigm in single-cell analysis that will open up new frontiers in life science research, precision medicine and diagnostics.

Presented Fluigent technology to the microfluidics community, by writing technical notes based on customers applications. Designed and improved setups for demo: droplets generation, double emulsion, flowmetry, Lab-on-a-Chip, valve actuation. Assisted microfluidic users on technical aspects including: o Presented Fluigent technical capabilities in microfluidics to users o Configured and designed microfluidic setups that satisfy the user’s requirements o Helped users with technical issues regarding Fluigent systems, and broadly on microfluidics, and programming Successfully designed and transferred worldwide-support management on CRM. Extensively continued with North America’s Sales.

Managed and shadowed projects for the Organ-on-Chip team such as: o Designing a novel microfluidic device for cell culture, making changes based on changing customer requirements, prototyping device using thermoplastic materials and hot-embossing, experimentally validating flow characteristics of device, writing record of invention to disclose novelty of device to patent lawyers o Renewing an auto-sampler program and creating an interface for microfluidic sensors Developed new pumping system for automated organs-on-chip instrument, extensively tested system for robustness to material choice, channel occlusions, and channel geometry, prototyped concept in multiple different functional organ-cartridges, tested and refined novel system for obtaining flow feedback in pumping system, helped compile records of invention for multiple aspects of system

Directed stock optimization project including: o Rearranging and cleaning, labeling and placing bar codes on over 6,000 maintenance mechanical pieces Successfully doing inaugural estimation of maintenance piece value to a total of 1€MM based on market price and depreciation of each item o Inputting and implementing 6,000 piece data into SAP o Training and transitioning 7 employees to continue stock evaluation upon departure

Performed maintenance on company’s main paper machine (100 meters in length) such as: o Fixing/changing 100+ pulleys that are used to transmit rotational speed to every rolling pin for paper o Testing and replacing (as needed) 100+ bearings from rollings o Changing 10-20 belts from paper machine engines

Designed, manufactured, and delivered hand-made metallic parts for chandeliers as such as “Chandelier Starck”

Study of hydrogels for microfluidics applications

Fluid Mechanics and Scaling Issues at the Microscale: Concept of Scaling Fluid Mechanics, Motion and Flow Principles Boundary Conditions The science of Bubbles, Drops, Surface tension, Wetting, and Diffusion Microfluidic System Fabrication: Fabrication Methods and Principles Choice of Materials (Silicon, PDMS,..etc) Bonding Techniques Micro Valves Micro Pumps Micro Channels Biological Detection and Medical Analysis: Detection Principles Issue of mixing, Heat control and exchange, pH, on-chip pumping and flow control Microarrays: DNA/RNA, Protein, Tissue Microfluidics for: - Separation and Electrophoresis - PCR Amplification - Flow Cytometry and Cell Sorting - SPR Clinical Applications of Microfluidic Devices: Integrated Devices: Design and Optimization Lab-on-a-chip Microfluidics for Medical Analysis and Diagnosis Drug High Through-put Screening Cancer Research

Concentration: Engineering Design Minor: Principles of Management for Engineers