Huan Lan

Associate Director of R&D @ Phrontline Biopharma

About

My training background is rooted in protein science and molecular immunology, with a specialized focus on the fundamental mechanisms of antigen presentation by MHC molecules and the regulation of intracellular signaling pathways in T cells. My research leverages fundamental techniques such as protein purification, protein engineering, protein-protein interaction analysis, microscopy and cell-based assays to explore the biochemical and molecular basis of adaptive immune response. Two years industry experience in antibody engineering and bispecific antibody platform. Professional experiences of handing on projects with high complexity with a record of accomplishment of significant deliverables (finished 5 projects in Academia and published 3 papers as 1st author and 7 papers as coauthors in the high-impacted journals). Efficient verbal/written communications, communicating the progress of projects with international collaborators and scientific community, including project progress reports in lab meetings and the oral/poster presentations in international conferences. Keen on disease-relevant researches, including identifying neoantigens, cell therapy, drug discovery.

Country

United States

City

South San Francisco

Industry

Pharmaceuticals

Skill

Project Management, Bispecific Antibody platform , Stable Cell Line, Condensates, Immunological Synapse, protein NMR, FP assay, Protein Chemistry, MHC-I protein expression and purification, Cryo-EM, Crispr, Antibody Engineering, bispecific antibody , Antibody Characterization including Tm, HPLC-SEC, HPLC-IEX, HIC, RPLS-RP, MS, Druggability Assessment , FACS analysis, OCTET, condensates, TCR-MHC interaction, Protein Characterization

Experience

Associate Director of R&D

Phrontline Biopharma

2025-9 - Present · 1 yr 1 mo

Shanghai, China

Responsible for the bispecific antibodies platform build and development Take lead action to explore and develop the next generation IO therapeutics

Postdoctoral Fellow

Genentech

2023-2 - Present · 3 yrs 8 mos

South San Francisco, California, United States

Protein Scientist

Abiosciences

2021-12 - 2023-2 · 1 yr 3 mos

Shanghai, China

worked as protein scientist in Abiosciences (shanghai) on antibody engineering (including QC) and development of bispecific antibody platform.

Postdoctoral Fellow

Freie Universität Berlin

2021-8 - 2021-12 · 5 mos

Berlin, Germany

Close up the the phd project for paper writing/publication.

Education

Freie Universität Berlin

Biochemistry

2016 - 2021 · 5 yrs

My PhD research topic is antigen presentation by MHCI molecules and proteins that coordinate intracellular signaling pathways in T cells. I have experiences in cell culture and have a good knowledge of cellular and molecular immunology. The main project during my PhD study is to investigate the mechanism of tapasin-catalyzed peptide exchange of MHC-I molecules. Tapasin, the key unit of the peptide loading complex, catalyzes the peptide exchange of suboptimal loaded-MHC-I molecules to form stable MHC-I molecules. I established the expression system of tapasin protein, the fluorescence polarization assays for catalytic activity testing and optimized the purification procedures of it, which made later assays possible. I applied biophysical methods (including NMR, SPR) to study the protein-protein interaction and identified the critical binding site. The research result has been submitted to nature communications.