Hongchang Qu
Associate Vice President @ Eli Lilly and Company
About
As a creative/productive scientist equipped with leadership skills and state of the art knowledge in organic synthesis, peptide chemistry, peptide lead optimization, process development, oral peptide formulation and delivery, and peptide-siRNA conjugation, I have contributed significantly to 14 patent filings and 12 candidate selections over the past few years. Eight peptides I co-invented went to clinical trials, with two started phase 3 - Mazdutide and Retatrutide. My goal is to make significant contributions to the marketing of innovative, affordable peptide drugs to meet the unmet needs of patients. Technology never stops advancing, I never stop learning and innovating. Below is a brief summary of my past achievements and expertise. * 2023 LRL President's Award: Deliver for patients - setting bold goals, work relentlessly to deliver real innovation to the patients * Two-time Lilly 2020 LRL PRESIDENT'S SCIENTIFIC AWARDS recognizing achievements beyond performance expectations for accomplishing a significant scientific achievement or contributing to the advancement of discovery, development, and commercialization of new medicines * Scientific leadership on hit to CS milestone of peptide therapeutics including peptide-siRNA conjugates * Leadership and scientific expertise on oral peptide engineering, formulation and delivery * Leading peptide SAR that led to patent filings and clinical testing of multiple novel therapeutic peptides (achieved 12 CS so far) * 30+ peer-reviewed papers in leading international journals * Proven abilities in multi-step synthesis, conjugation, labeling, purification and characterization of small organic molecules, unnatural amino acids, and bioactive peptides/peptidomimetics. * Peptide/peptidomimetic drug design and lead optimization * Successfully developed several robust chemical processes for manufacturing small molecules and complex peptides Specialties: peptide/peptidomimetic drug design; structure-activity relationships; multi-step synthesis; process development, DOE, solid phase peptide synthesis; solution phase peptide synthesis; microwave synthesis; fluorescent labeling; PEGylation; biotinylation; conjugations; NMR, HPLC/UPLC, LC-MS/MS, UV, IR, ELISA, ITC (isothermal titration calorimetry), SPR (surface plasmon resonance); peptide synthesizer; column packing
United States
Indianapolis
Pharmaceuticals
Organic Chemistry, GMP, NMR, Medicinal Chemistry, LC-MS, HPLC, Mass Spectrometry, UV/Vis, Analytical Chemistry, Purification, IR, Peptide Chemistry, Processes Development, Complement inhibitor, Peptides, Peptide Synthesis, Process Simulation, Characterization, ELISA, NMR spectroscopy
Experience
Associate Vice President
Eli Lilly and Company
United States
Executive Director - Chemistry / Group Leader - Peptide Therapeutics
Eli Lilly and Company
Indianapolis, Indiana, United States
Senior Director - Chemistry / Group Leader - Peptide Therapeutics
Eli Lilly and Company
Indianapolis, Indiana, United States
Research Advisor / Senior Director - Chemistry, Peptide Therapeutics
Eli Lilly and Company
Indianapolis, Indiana Area
* Portfolio project Scientific Team Leader - peptide therapeutics for the treatment of diabetes, obesity, NASH, etc. * Portfolio project Lead Chemist - peptide therapeutics for the treatment of diabetes, obesity, NASH, etc. * Peptide-siRNA lead optimization * Oral peptide structure-activity-relationship * Exploratory work with cross-functional teams in the pre-portfolio space
Senior Research Scientist - Peptide Therapeutics
Eli Lilly and Company
Indianapolis, Indiana Area
*Portfolio project Lead Chemist *Achieved candidate selection for multiple peptide projects targeting indications including diabetes, obesity, NASH, etc.
Research Scientist - Peptide Therapeutics
Eli Lilly and Company
Indianapolis
* Portfolio project Lead Chemist, achieved candidate selection for multiple peptide projects targeting indications including diabetes, obesity, and NASH, etc * Founding member of new oral peptide formulation and delivery platform * Optimized peptide in vitro/in vivo potency/efficacy, permeability, stability, PK/PD, developability, immunogenicity, safety, etc. * Supported clinical studies of therapeutic peptides * Supervised associates supporting multiple peptide projects
Process Development Scientist
PolyPeptide Group
Torrance, CA
- Developed processes for the manufacturing of complex non-GMP and GMP grade therapeutic peptides as well as their PEG conjugates - Developed a process to generate critical impurities for preclinical toxicology studies - Wrote process development reports and participated regular project update meetings with leading pharma customers
Postdoctoral Researcher
University of Pennsylvania
* Developed the most potent analogues of peptide drug candidate compstatin resulting in filing of patents * Significantly improved solubility and pharmacokinetic properties of the leading compstatin analogues * Significantly contributed to the development of a novel peptide that can protect nonself surfaces against complement attacks * Synthesized/prepared peptide/peptidomimetic reagents to support investigation of therapeutic effects of various complement inhibitors for the treatment of AMD, transplant rejection, sepsis, among others
Teaching/Research Assistant
University of Arizona, Tucson, AZ
* Developed series of novel hMC4R selective peptidomimetics as potential drug leads * Developed novel methodologies for the asymmetric synthesis of anti-beta-substituted gamma,delta-unsaturated amino acids * Performed gram-scale multi-step synthesis of 2',6'-dimethyl-β-methyl tyrosine and Fmoc-4-N,N'-di-Boc-guanidinoproline * Instructed and supervised undergraduate students in general and organic chemistry labs * Tutored undergraduate students to support chemistry lecture courses
Senior Chemist
SC Johnson Professional, Shanghai, China
* Developed several new industrial mechanical warewashing detergents and laundry products * Supported the in-house manufacturing of copolymers and industrial floor finishes * Provided product application technical support to customers and the sales team
Process Chemist
Pilot Plant of Shanghai Institute of Organic Chemistry, CAS, Shanghai, China
* Established process for kilo-scale multi-step synthesis of 2,3,4,5-tetrafluorobenzoic acid * Improved yield of 3-methoxy-2,4,5-trifluorobenzoic acid methyl ester hydrolysis by 50% via process optimization * Supervised manufacturing of 3-methoxy-2,4,5-trifluorobenzoic acid
Education
University of Arizona
Organic Chemistry
Dr. Victor J. Hruby Group
University of Pennsylvania
Complement therapeutics
East China University of Science and Technology
Chemical Engineering
Hongchang Qu's Contact Information
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