Guoping X.

Director of PK/PD @ HighTide Therapeutics

About

• Over 8 years of experience in small-molecule drug discovery. Specialized in DMPK and PK/PD, with a proven track record of advancing compounds from lead optimization to IND filing. • Demonstrated leadership in LC-MS-based bioanalysis, in vitro ADME, in vivo PK/PD, human PK prediction, PK/PD modeling, exploratory toxicology, and dose/regimen selection. • Known for strong cross-functional communication and the ability to align DMPK strategy with project goals. • Effective in CRO management and building internal capabilities, with experience setting up DMPK and LC-MS labs. • Key contributor to four successful IND applications and co-inventor on four patent filings.

Country

China

City

Shanghai

Industry

Pharmaceuticals

Skill

Monolix, gastroplus, 良好实验室操作规范, 良好药品临床试验规范, Berkeley Madonna, PK-Sim, chromatography, NMR, Gaussian 03, PK/PD modelling, Toxicokinetics, Research & development, ADME, ADMET, Toxicology, Project management, Drug Discovery, PK/PD, Bioanalysis, Metabolomics

Experience

Director of PK/PD

HighTide Therapeutics

2023-8 - 2025-4 · 1 yr 9 mos

中国上海市

• Led DMPK and toxicology strategy across the research portfolio, enabling 2 PCC nominations and 3 Lead identifications. • Designed and interpreted in vitro ADME, in vivo PK, and non-GLP toxicology studies, generating critical data for decision-making. • Partnered with the Pharmacology lead to troubleshoot efficacy and safety challenges using exposure-based insights. • Acted as a primary liaison with CROs, enhancing deliverable quality and efficiency through scientific oversight. • Co-inventor on 4 patent applications, contributing to project intellectual property.

DMPK Director

Fosun Pharma

2021-3 - 2023-7 · 2 yrs 5 mos

中国上海市浦东新区

• Served as DMPK lead for six discovery programs in oncology and nephrology, supporting 4 IND-enabling packages. • Delivered integrated PK/PD and modeling strategies to inform candidate selection and FIH dosing. • Provided DMPK insight to support preclinical safety evaluations and address key development hurdles. • Designed the DMPK laboratory at the Global R&D center.

Principal Scientist

WuXi AppTec

2018-8 - 2021-3 · 2 yrs 8 mos

Shanghai City, China

• Operated at the interface of biology and DMPK, led in vivo PK/PD, tissue distribution, and in vivo efficacy studies across 5 early-stage projects in metabolic and renal indications. Enabled in vivo proof-of-concept and PCC nomination. • Founded and managed the LC-MS lab, performing fit-for-purpose and reliable bioanalysis to accelerate lead optimization and IND preparation. • Designed and delivered studies in in vitro stability, cellular uptake/metabolism, and brain penetration, facilitating data-driven decision-making in dynamic project settings.

Senior Scientist

ChemPartner

2017-4 - 2018-7 · 1 yr 4 mos

Shanghai, China

• Developed and validated LC-MS bioanalytical methods for diverse NCEs and endogenous biomarkers. • Executed PK and PD studies across multiple client programs, consistently meeting tight timelines • Managed project pricing, client communication, and protocol design, building strong partnerships and earning client trust.

Postdoctoral Research Fellow

Fudan University

2014-9 - 2017-4 · 2 yrs 8 mos

Shanghai

• Developed targeted metabolomics workflows to study the in vivo function of hydroxysterols. • Managed and expanded the university's Metabonomics platform, enabling high-quality Metabonomics research. • Mentored graduate students and delivered training on LC-MS-based metabolomics and quantitative bioanalysis.