Gor Sarkisyan, Ph.D.

Developing an accessible diagnostic tool for Mytonic Dystrophy Type 2. We believe that our work will positively impact our patients by providing answers that they have, supporting treatment, and alleviating from social burden and misunderstanding that they face daily in their personal and professional lives.

Decano Analytical Laboratories, LLC. is a multi-profile analytical testing laboratory providing services to the cannabis industry. We specialize in testing for the presence of pesticides and heavy metals as well as microbial contamination. Our services cater to the pharmaceutical industry by studying pharmaceutical agent stability, purity testing, metabolite analyses, and characterization of drug interactions.

• Experimental setup, development of assay strategy and protocol development • Develop and troubleshoot innovative in vivo models of Ulcerative Colitis. • Intravital Imaging and in vivo inflammation and immunomodulation. • Characterization blood and lymphatic vessel stability lymphocyte infiltration and arrest in inflamed tissues.

• Developed company’s proprietary technology and ensuring their security by patenting with the international Patent Cooperation Treaty (PCT). • Design, planning and managing laboratory • Responsible for managing junior personal. • Scheduling and oversee fast-paced daily work of research associates. • Developed holographic tracking technology in support of high impact communication. • Proactively manage company’s product research and development. Quality control and testing. • Published 2 government access only white papers with the Office of Naval Research. • Write and make presentations of progress reports to military officials at the Naval Research Laboratories.

• Generation and manufacturing of human CAT-T cells • CAR-T cell production scale-up • In vivo studies of sCAR T cell/switch efficacy in mouse and rat tumor models • R&D in support of generation memory CAT-T cell phenotype in support of IND • Modification and characterization of preparatory “switch” for switchable CAR-T cell (sCAR-T cell) therapies • T cell activation, differentiation and phenotyping, characterization of cytokine production and receptor expression

• Ecology and Environmental Sustainability (SCI201) • Contemporary Application of the Sciences (SCI215)

• Experimental setup to study tumor development and vascularization in PyMT and 4T1 xenograft model of mouse breast cancer. Modulation of tumor development rate and rate of metastasis using S1PR1 specific pharmacological tools • In vivo development, validation, and assessment of efficacy and pharmacodynamics in tumor models labeling and analysis method for blood and lymphatic system and microfluidic flow in live animals. • Multiphoton intravital imaging to investigate tumor growth microenvironment and vascularization, metastasis, and tumor marker specific immunoglobulin conjugated drug delivery. Imaging for native protein detection and analysis of S1P1 and S1P3 activation, internalization and degradation dynamics. • Responsible for experimental design, executing and conducting experiments, and data analyses • Training multidisciplinary researchers in experiment setup procedures and data analyses. • Write and review of scientific article and manuscripts for publication.

• Mouse colony maintenance, genotyping and breeding. • Mouse models of depression: forced swim and tail suspension behavioral despair tests in 5-HT7 knockout and wild type mice. • 5-HT7 mediated disruption in memory formation, consolidation or retrieval. • Novel object recognition, place learning and cue discrimination, Morris water maze, Barnes maze • Bromodeoxyuridine (BrdU) based Immunohistochemistry on neuronal development in adult hippocampus • Development for 5-HT7 small molecule screening assays. • Responsible for behavioral characterization of pharmacological modulation of 5HT-7.

Biology

Molecular Biophysics