Genliang Lu
Senior Director, Medicinal Chemistry @ Wave Life Sciences
About
Expertise and experience in multiple areas: medicinal chemistry, process chemistry, synthetic organic chemistry and solid phase synthesis. Strengths include: lead generation and lead optimization using structure-activity relationship and pharmacokinetics; spectroscopy (NMR, MS, UV-VIS, FTIR) and separation methods (HPLC, UPLC, LC-MS, flash chromatography, TLC, GC); strong problem-solving skills in medicinal chemistry and process chemistry.
United States
Greater Boston
Pharmaceuticals
Medicinal Chemistry, Drug Discovery, Synthetic Organic Chemistry, Drug Design, Analytical Chemistry, Process Chemistry, Analytical Methods Development, Analytical Method Validation, Radiochemistry, Quality Control, Stability Programs, Sop, CMC, Lifesciences, IND, Biotechnology, GMP, Technology Transfer, Validation, Chemistry
Experience
Senior Director, Medicinal Chemistry
Wave Life Sciences
Cambridge, Massachusetts, United States
Director, Medicinal Chemistry
Wave Life Sciences
Cambridge, Massachusetts, United States
Principal Scientist
Wave Life Sciences
Cambridge, Massachusetts, United States
Senior Scientist
Wave Life Sciences
Cambridge, Massachusetts, United States
Senior Scientist
Synta Pharmaceuticals
Lexington, MA
Designed and synthesized HSP90 inhibitor drug conjugates (HDCs) with multiple HSP90 inhibitors, various payloads and linkers to expand HDC platform and intellectual properties (IP) coverage. Designed and synthesized HD-conjugated docetaxel and carfilzomib lead compounds.
Senior Scientist
Molecular Insight Pharmaceuticals
Cambridge, MA
Designed and first synthesized several clinical candidates for prostate cancer and solid tumor including a phase III clinical candidate (MIP-1404). Designed and synthesized a series of highly potent Tc/Re-PSMA inhibitors for the diagnosis and staging of prostate cancer. Designed and synthesized Lu-DOTA PSMA inhibitors for therapeutic application of prostate cancer. Designed and synthesized CA IX inhibitors with Re/Tc to for targeted molecular imaging of hypoxia solid tumor.
Research Scientist
Cumbre Pharmaceuticals Inc.
Dallas/Fort Worth Area
Synthesis and development of oxazolidinone-nitroimidazole (Oxz-Ntz) hybrid lead compounds for TB alliance project, which exhibit better activity than PA-824 or linezolid against BCG or TB strain. Detailed SAR study for Oxz-Ntz hybrids including ether linker, amine linker and biaryl linker for TB alliance project. Synthesis and development of chemistry lead compounds (Oxz-Met hybrids) for C. difficile associated disease project.
Education
South Dakota State University
Organic Chemistry
Texas A&M University
Organic Chemistry
The University of Kansas
Organic Chemistry
Zhejiang University
Organic chemistry
Genliang Lu's Contact Information
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