Gayathri Jeyasankar
Research Scientist Cryo-EM @ PROTEROS biostructures GmbH
About
As a passionate structural biologist with a strong background in Cryo-EM and protein biochemistry, I thrive at the intersection of science and innovation. Over the past 4+ years, I’ve advanced structure-based drug discovery projects, accelerating early-stage therapeutics through high-resolution protein-ligand complex studies.Beyond the bench, I enjoy cross-functional collaboration, mentoring junior scientists, and optimizing workflows to drive impactful outcomes. I'm excited about opportunities to bridge structural insights with therapeutic innovation, particularly in unmet medical need and rare diseases.I’m always open to connecting with fellow scientists, and innovators. Let’s discuss how structural biology can shape the future of drug discovery!
Germany
Greater Munich Metropolitan Area
Biotechnology
Lead Selection, Pre-clinical safety, Pre-formulation, Target Identification, Pharmacokinetics, Emotional Management, Drug Discovery, Drug Development, Assay Development, cGxP, Good Laboratory Practice (GLP), Good Manufacturing Practice (GMP), Project Management, Teamwork, Data Analysis, Project Documentation, Organization Skills, Analytical Skills, Communication, Research Skills
Experience
Research Scientist Cryo-EM
PROTEROS biostructures GmbH
Planegg
-End-to-end completion of several Single particle Cryo-EM projects of GPCR-Ligand complexes, Membrane proteins-Ligand complexes, Antigen-antibody complexes, DNA-Protein complexes: 20+ high-resolution (2.2-3.4 Å) structures, including novel structures that are part of a peer-reviewed publication. -Evaluation and planning of projects, including strategies for protein production and structure determination by Cryo-EM. -Standardization of protocols and workflows as part of establishment of the Cryo-EM Team and Facility. -Operation and data acquisition: TEM-Glacios. -Troubleshooting -Data analysis and interpretation -Communication of complex scientific data with internal and external stakeholders -Cross-functional collaboration -Scientific writing -Supervision
Postdoctoral Researcher
University of Cologne
-Single particle Cryo-EM to understand structural dynamics of light sensitive cryptochrome, metallo proteases, cyclic nucleotide gated ion channels. -Label-free mass spectrometry and phosphopeptide analysis of membrane protein purified from native source. -Supervision of PhD student. -Teaching: Practical course, M.Sc. Biochemistry, on single particle Cryo-EM data processing workflow. -Overseeing tasks of a technical assistant. -Operation and data collection, TEM: TITAN Krios, Talos Arctica, JEOL JEM-2200 FS.
Postdoctoral Researcher
Max Planck Institute for Neurobiology of Behavior
Employer for part of the same Postdoctoral Researcher position as above
Doctoral Candidate
Max Planck Institute for Neurobiology of Behavior
-Extraction and purification of membrane proteins from an endogenous source. -Membrane proteins reconstitution techniques - Nanodiscs, Amphipols, Saposin-lipoprotein systems and SMALPs. -Surface modification techniques for cryo-EM sample preparation - Graphene Oxide and monolayer Graphene coating of EM grids and preparation of Ni-NTA afifnity-based EM grids. -Protein expression and purification of membrane scaffold proteins. -Protein stability by thermal shift assays (Prometheus). -Protein-ligand interaction studies (Fludity-One W). -Operation and data collection, transmission electron microscopes: TITAN Krios, Talos Arctica, JEOL JEM-2200 FS, LEO 922 (ZEISS).
Master Thesis
The Julius Maximilians University of Würzburg
Institute of Neurobiology and Genetics, University of Wuerzburg, Germany
Title: Spatial and temporal localization of period mRNA and protein in the brain of Drosophila melanogaster.
Teaching Assistant
Kattaikkuttu Sangam
Kanchipuram, Tamil Nadu
-Teaching for primary and secondary school level English and Mathematics.
Bachelor Thesis
Centre for Cellular and Molecular Biology
CCMB, Hyderabad Area, India
Title: Designing drug leads that target intrinsically disordered proteins of Mycobacterium tuberculosis.
Indian Academy of Sciences, Summer Intern
Centre for Cellular and Molecular Biology
Hyderabad Area, India
-Protein Expression and Protein Purification of different soluble proteins. -Biophysical characterisation of calcium binding proteins by isothermal titration calorimetry and fluorescence spectroscopy.
Education
The University of Bonn
Molecular Biomedicine
The Julius Maximilians University of Würzburg
Life Science
PSG College of Technology
Biotechnology
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