Gamze Camdere Tapia

Senior Principal Scientist @ Amgen

About

Protein engineer passionate about understanding mechanisms by which proteins behave and misbehave, and how they can be targeted for therapeutic intervention. Leading a team in display technology. While I have a connection to Amgen, opinions are my own and do not represent Amgen’s position.

Country

United States

City

Los Angeles Metropolitan Area

Industry

Biotechnology

Skill

Structural Biology, Biochemistry, Molecular Biology, Cell Biology, membrane trafficking and curvature, chromatin structure, Confocal Microscopy, Genetics, Fluorescence Microscopy, Cell Culture, Protein Chemistry, In Vitro, DNA, Microscopy, Lifesciences, Genomics, Cancer, Molecular Cloning, Protein Expression, Western Blotting

Experience

Senior Principal Scientist

Amgen

2024-4 - Present · 2 yrs 6 mos

Thousand Oaks, California, United States

Principal Scientist

Amgen

2022-3 - Present · 4 yrs 7 mos

Scientist

Amgen

2018-6 - 2022-3 · 3 yrs 10 mos

Scientist II

Bristol Myers Squibb

2018-5 - 2018-6 · 2 mos

Redwood City

Protein engineer

Scientist I

Bristol Myers Squibb

2016-6 - 2018-5 · 2 yrs

Redwood City, CA

Protein engineer

Damon Runyon Postdoctoral Fellow

University of California, Berkeley

2012-9 - 2016-6 · 3 yrs 10 mos

Berkeley, CA

I use structural biological analysis and in vitro assays to understand how a protein called cohesin interacts with DNA. During cell division, cohesin is the protein complex that holds sister chromatids (replicated chromosomes) together until the onset of cell division, when each copy goes to one daughter cell. Cohesin is required for proper chromosome segregation, DNA repair, gene expression, and overall maintenance of genomic integrity. A better understanding of cohesin will provide important insights into chromosome organization and biology, as well as shed light onto the pathology of cancer.

Postdoctoral Scientist

University of California Berkeley

2011-9 - 2016-6 · 4 yrs 10 mos

Berkeley, CA

Kim SX, Çamdere G, Hu X, Koshland D†, Tapia H†. "Synergy between the small intrinsically disordered protein Hsp12 and trehalose sustain viability after severe desiccation." Elife. 2018 Jul 16;7. pii: e38337. doi: 10.7554/eLife.38337. Camdere G, Guacci V†, Stricklin J, Koshland D†. “The ATPases of cohesin interface with regulators to modulate cohesin-mediated DNA tethering” eLife (Elife. 2015 Nov 19;4. pii: e11315. doi: 10.7554/eLife.11315.) Stigler J, Çamdere GÖ, Koshland DE†, Greene EC†. "Single-Molecule Imaging Reveals a Collapsed Conformational State for DNA-Bound Cohesin" Cell Reports 2016 May 3;15(5):988-998. doi: 10.1016/j.celrep.2016.04.003. Epub 2016 Apr 21.

PhD student

University of Cambridge, MRC-Laboratory of Molecular Biology

2007-9 - 2011-7 · 3 yrs 11 mos

Cambridge, United Kingdom

Meinecke M†, Boucrot E, Camdere G, Hon WC, Mittal R, McMahon HT†. "Cooperative recruitment of dynamin and BIN/amphiphysin/Rvs (BAR) domain-containing proteins leads to GTP-dependent membrane scission." J Biol Chem. 2013 Mar 1;288(9):6651-61. doi: 10.1074/jbc.M112.444869. Epub 2013 Jan 7. Boucrot E*, Pick A*, Camdere G*, Liska N, Evergren E, McMahon HT†, Kozlov MM†, “Membrane fission is promoted by shallow hydrophobic insertions while limited by crescent BAR domains" (Cell, 2012 Mar 30;149(1):124-36.) LLobet A*, Gallop JL*, Burden JJE, Camdere G, Chandra P, Vallis Y, Hopkins CR, Lagnado L†, McMahon HT† “Endophilin Drives the Fast Mode of Vesicle Retrieval in a Ribbon Synapse”, J Neurosci 31, 8512-8519, doi:10.1523/JNEUROSCI.6223-09.2011 (2011). *equal contributions, †corresponding authors