gajanan inamdar

* Set-up a fully functional chemistry lab at the department of pharmacology. * Lead optimization of a naturally occurring triterpene using multi-step synthesis for screening against metastatic melanoma. * Assessed biological potency, selectivity in cell based assays & interacted with team in cancer biology, pharmacology, and toxicology groups. * Analysed SAR according to cell culture and molecular-biology findings. * Successfully completed lead optimization within one year that resulted in the selection of a group of compounds that went on to an advanced stage of in vivo studies. * Collaborated in optimisation of LCMS method to evaluate pharmacokinetics of the lead in mice and rats. * Actively participated in the preparation of patents, publications, project drafts & planning/reporting.

* Led a team of for a drug modification program focused on optimising PK/PD profile and re-purposing. * Designed, planned and executed multi-step organic synthesis and purification for the production of libraries of drug-like compounds based on the lead 11β-hydroxy steroid to target mitochondrial depletion/disintegration related conditions. * Dynamically participated interacted with colleagues in biology, pharmacology, and DMPK groups. * Evaluated SAR according to pharmacological, solubility and PK/PD results * Designed & synthesised reagents using GRAS (generally recognised as safe) synthons, assessing synthetic feasibility and safety characteristics of chemistry libraries.

* Participated in stability studies of active pharmaceutical ingredients and formulations for ANDA. * Method validation of stability indicating HPLC of formulations and related substances. * Method development and validation of other volatile impurities using gas chromatography. * Method transfers to plant facility. * Data compilation and documentation

Being a leading pharmaceutical firm, Zydus Cadila Healthcare relies heavily on drug research and development. I supported drug research and drove the drug approval process by conducting stability studies of active pharmaceutical ingredients (APIs) in new drug products. I also aligned internal standards on drug development and manufacturing with the USP Reference Standards. Finally, I calibrated all analytical instruments while meeting tough deadlines. Specialties: Pharmaceutical Research, Drug Testing, Chemistry, Drug Development, Data Analysis, Drug Characterization Techniques.

* Led a group of chemists working on a kinase based drug discovery program for a UK based start-up. * Designed, planned and executed multi-step organic synthesis and purification of target molecules for biological screening. * Problem solving of flaws in synthetic schemes and process. * Assisted team leader and group leader in the planning and management of research efforts, including data mining and documentation for clients. * Prioritized the chemistry efforts to ensure timeline adherence and project alignment to meet group, company & client goals. * Participated in formal & informal brainstorming discussions and contributed to new suggestions and ideas. * Team management, and proposed timelines supervised workflow, deadlines and project reports. * Actively participated in the preparation of patents, publications, and project planning/reporting. * Leadership role in interviewing, hiring and mentoring new chemists and scientists.

Research on Desin & Synthesis of Thiazole Derivatives as Ligands for Adenosine Receptors under Dr. Kamala K. Vasu, at B. V. Patel Pharmaceutical Education and Research Development (PERD) Centre"]