Francis Eze

Designed and synthesized 15+ triazole-based coumarin-thiazole inhibitors targeting Factor XIIa (FXIIa), achieving nanomolar IC₅₀ values (~100% in vitro efficacy), contributing to a new lead series for contact-pathway anticoagulation. Synthesized 5 next-generation sulfated plasmin inhibitors with >300-fold selectivity for plasmin over thrombin (FIIa) and Factor Xa, a major advance toward bleeding-safe antifibrinolytic therapy. Developed high-throughput NSGM functionalization workflows enabling kinetic profiling of 20+ candidate molecules per screening cycle. Performed SAR analysis with AutoDock Vina/PyMOL docking to rationalise structure-activity trends and drive iterative library design. Applied photoaffinity labelling to map NSGM-protein binding domains and elucidate inhibitor mechanisms of action. Established LC-MS/NMR end-to-end characterisation pipeline, accelerating compound turnaround from synthesis to biological testing. Mentored 3 undergraduate researchers; set up and managed a new medicinal chemistry lab, including equipment installation, safety protocols, and team training.

Graduate Students' Welfare Advocacy Led Family Science Night Outreach at Liberty Elementary School, Flower Mound Led Mad Science outreach for the Denton Community Led National Chemistry Day Outreach at Denton High School

Expressed and characterised nonribosomal peptide synthetases (NRPS) heterologously in Aspergillus oryzae to activate cryptic biosynthetic gene clusters. Optimised fermentation conditions for Colletotrichum spinosum CBS 515.97, leading to the discovery and structural elucidation of a novel thielavin derivative (3''-demethylthielavin) and multiple alkaloids — published in Chemistry & Biodiversity (2025). Integrated LC-MS/MS, NMR, antiSMASH, and BLAST genome mining to map gene-to-metabolite relationships in underexplored fungal systems.

T.A. for CHEM 1410 (General Chemistry 1) - Taught/Planned laboratory lessons and demonstrations for Science Majors and Non-Majors. T.A for CHEM 1420 (General Chemistry 2) - Assisted in planning lessons and assignments for science majors. Organized and led discussion sessions, graded assignments, quizzes, and exams.

Branding | Business Logos | Banners | Business Cards | Digital Flyers | Ad Posters | Photomanipulation | Music Art Cover

One year Mandatory National Youth Service

Collection and collation of data, making calculations, preparing reports, keeping records and making independent decisions. Preparation of concept notes on raw materials needs of local industries. Other statutory duties assigned by the management and supervisor.

Assisted in carrying out both undergraduate and graduate research projects and accurate recording of results. Assisted in organizing of 2016 African Biochemists Entrepreneurship Program. Prepared laboratory reagents for different biochemical analysis. Organized and maintained laboratory instruments, equipment and reagents. Trained on the use of Spreadsheet in reporting research results and use of laboratory equipments

Assisted in carrying out both undergraduate and graduate research projects and accurate recording of results. Assisted in organizing of 2016 African Biochemists Entrepreneurship Program. Prepared laboratory reagents for different biochemical analysis. Organized and maintained laboratory instruments, equipment and reagents. Trained on the use of Spreadsheet in reporting research results and use of laboratory equipments.

Assisting in organizing yearly seminar for prospective and past graduates of Applied In Nnamdi Azikiwe University Awka

-Studied the biological the biological processes that occur in human body through the chemistry of Proteins,Lipids, Carbohydrates and Nucleic acids. -Gained theoretical knowledge of Genetic Engineering,Cloning and Biotechnology. -Underwent Laboratory Trainings.

A 6 month Pre degree program in preparation for admission into Undergraduate level.