Feng Liu

1. Co lead multiple projects of siRNA for extra-hepatic and liver diseases 2. Deliver expert guidance to multi disciplinary teams such as DMPK, bioconjugation teams 3. Track record of generating results 4. Collaborate with other teams to support project s for nomination, such as CNS and muscle projects 5. Assemble a team of PhD educated scientists 6. Manage internal scient ists to support multiple projects 7. Set up chemistry lab in new site 8. Oversee work in internal facilities and with external vendors 9. Extensive experience in developing platform for siRNA delivery for extra-hepatic diseases 10. Optimiz ed sense strand and antisense strand to increase siRNA efficacy and stability 11. Modified nucleoside s to increase siRNA efficacy and stability 12. Design ed and synthe sized key linker for siRNA delivery in muscle pro ject which saved significant amount of money and time for CMC

R&D on new fluorescent probes and producing customer ordered chemicals and probes 1. Synthesized and delivered customer ordered fluorescent probes and chemicals within deadline 2. Developed novel Ca2+ chelator 3. Developed novel Ca2+ fluorescent indicator 4. Synthesized novel monomers used in fluorescent polymer dyes 5. Optimized synthetic routes for several existing products

Synthesis of multiple Mycobacerium turerculosis inhibitors and test of their biological activities 1. Chemistry effort <1>Optimized Mycobacterium tuberculosis transaminase inhibitors by structure-based strategy <2>Total-synthesized Mycobacterium tuberculosis siderophores mycobactin T and carboxy mycobactin <3>Synthesized N-acetyl-N-hydroxy-L-lysine <4>Synthesized Mycobacterium tuberculosis transition-states salicylate synthase inhibitors 2. Biology effort <1>Overexpressed and purified Mycobacterium tuberculosis transaminase <2>Overexpressed and purified Mycobacterium tuberculosis enoyl-ACP reductase <3>Determined binding affinity between Mycobacterium tuberculosis biotin protein ligase and its inhibitors by direct and competitive isothermal titration calorimetry <4>Determined binding affinity between Mycobacterium tuberculosis transaminase and its inhibitors by direct isothermal titration calorimetry <5>Determined binding affinity between Mycobacterium tuberculosis transaminase and small fragments by direct isothermal titration calorimetry

1. Synthesized HIV reverse transcriptase-associated ribonuclease H inhibitors 2. Synthesized human cytomegalovirus inhibitors

Synthesized new Schiff base complexes (Ni, Cu) and other Ni, Cu, Fe complexes

1.Collected/reviewed data and built/maintained pharmaceutical database; 2.Provided data support for the Unlimited Competitive Open Bidding of Drugs used in Hospitals in Hebei Province 2003

1.Synthesized standard compounds at small scale; 2.Tested solid dosage content using HPLC and titration methods; analyzed and documented test results within deadlines; reported omission or irregularity

Thesis: Synthesis of Natural Products and small molecules Using Quinones