Eric Danner
Senior scientist, Genome Editing - CMC & Preclinical interface @ T-knife Therapeutics
About
Passionate problem solver who built my career entering new fields. Successfully entered and managed preclinical, model generation, gene editing, and LIMS implementation projects. Experience on gene editing projects wet-lab, computationally, and management. Led an empowered diverse group. Strong internal and external cross functional team experience. Experienced in clinical and preclinical gene editing. US-European collaboration work culture with 10 + years working in the US and 10+ years in Germany/Europe. Supported partner companies in the US and Europe for CTA filing.
Germany
Berlin Metropolitan Area
Biotechnology
Line Management, Next-Generation Sequencing (NGS), nonclinical, Genetics, Team Leadership, Laboratory Information Management System (LIMS), Cell Line Development, Data Modeling, Transgenic Mice, Research and Development (R&D), Mouse Models, Pre-clinical Studies, Data Management, People Management, Experimental Design, Molecular Genetics, T cells, Education, Chemistry, Biochemistry
Experience
Senior scientist, Genome Editing - CMC & Preclinical interface
T-knife Therapeutics
Berlin, Germany
T-knife Therapeutics is a cellular immunotherapy company dedicated to developing treatments to fight solid cancers. The company is focused on T cell receptor (TCR) engineered T cell therapies (TCR-Ts). The company’s unique approach is based on its proprietary MyT TCR discovery platform; this T-cell receptor and epitope discovery tool produces fully human, tumor-specific TCRs, selected in-vivo for optimal affinity and high specificity. Senior scientist, Genome Editing - CMC & Preclinical interface - Designed and delivered preclinical genotoxicity package for filed CTA filing - Analytical development for characterization and release assays - Designed and implemented genotoxicity assays for R&D and GMP-like materials for CTA - participated in EU regulatory feedback and contributed to CTA filing - Worked across departments - Led design and analysis for testing involving Guide-seq, Safer-seq, One-seq, deux-seq, scAMP-seq, dGH, g-banding, dPCR, rhAMP-seq - Managed internal and external projects MyT Platform Team Lead - Led a team of 5-7, reporting directly to CTO - Maintained >15 mouse lines housed across multiple sites - Designed, generated, and characterized >10 mouse models LIMS system owner - Selected and implemented firms laboratory information management system - Designed data model and system owner of >55 active users
Doctoral Student
Max Delbrück Center
Berlin, Germany
Education
Max Delbrück Center
Genetics
Eric Danner's Contact Information
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