Dr. Kranthi Raj K

I am a computational chemist by training (Ph.D., in Computational Chemistry). My career began in the biotech industry at GVKBIO (now Aragen Life Sciences), and I currently serve as Chief Scientific Officer (CSO) at PozeSCAF Inc. At PozeSCAF, I lead AI and CADD-enabled drug discovery across small molecules and biologics—driving programs from target identification through IND. I have worked on 50+ targets, with multiple assets progressing to clinical trials. I design discovery pipelines that integrate: 🔹 rapid triage of large chemical libraries 🔹 realistic fit-testing on biological targets 🔹 motion-aware stability checks with physics-guided scoring 🔹 synthesis-aware lead optimization I collaborate closely with AI/ML and deep learning teams to build predictive models for ADMET, selectivity and off-target effects and to leverage generative design for high-value chemical space exploration. My target experience spans kinases, GPCRs, DNA-repair proteins, ion channels, transporters, peptides/antibodies, protein therapeutics and membrane proteins—covering disease areas including oncology, immunology, inflammation, CNS, metabolic disorders and infectious disease. I am passionate about new-generation modalities such as PROTACs, molecular glues, PPI modulators, peptide–drug conjugates (PDCs) and antibody–drug conjugates (ADCs). Known for cross-functional leadership across AI, computational chemistry, medicinal chemistry, biology and preclinical teams, I also maintain an active scholarly presence with 26 publications and patents across therapeutic domains. 💬 Let’s connect and discuss your requirement.