giovanna de filippi

* EC-Lab is the exclusive distributor in UK and Ireland for BioLogic Science Instruments (SAS) and their complete product range including: * More than 20 potentiostats/galvanostats from single- to multichannel systems * Battery cyclers * Impedance analyser and conductivity meter * Scanning systems

* In vitro/in vivo electrophysiology group leader with responsibility for the scientific and technical coaching of associate, undergraduate and PhD CASE students. * Established, validated and implemented in vitro and in vivo electrophysiological assays to support drug discovery projects in the DHT portfolio (e.g. mGluR ligands, PDE inhibitors). * Leadership of a schizophrenia focus group team of peers from different functions at two geographical locations: tracking and advancement of pre-portfolio projects, competitive landscape, monitored external opportunities for medium- to long- term investment. * Management of the outsourcing of electrophysiology work to CROs. * New/novel targets assessment for psychiatric indications. * Presented to relevant project teams, committees, and management on data supporting drug discovery projects, project reviews, new drug discovery targets proposal.

* Patch-clamp group leader with responsibility for the scientific and technical coaching of associate, undergraduate and PhD CASE students. * Project leadership in a cannabinoid ligand drug discovery effort for pain indication. * New/novel targets assessment for pain indications. * Design and validation of in vitro assays to support drug discovery projects for pain indications. * Evaluation of new technologies for the study of ion channels and transporters. * Presented to relevant project teams, committees, and management on project reviews, new drug discovery targets proposals, data supporting drug discovery projects, evaluation of new technologies.

* Patch-clamp group leader. Line management of an associate; responsibility for the scientific and technical coaching of associate, undergraduate and PhD CASE student. * Accountable for the delivery of key data to drug discovery projects supported using patch-clamp electrophysiology in neuronal primary cultures and recombinant cell lines (e.g. nAChR ligands; D-serine/glycine modulation of NMDA receptors). * Project leadership in early stages drug discovery projects including an enzyme inhibitor and a Na/Ca exchanger inhibitor. * Evaluation of new/novel instrumentation for electrophysiological recordings; due diligence evaluation and visit to selected automated patch-clamp providers. * Participated in the New Target Team activities for assessing competitive landscape and new targets for psychiatric indications. * Presented to relevant project teams, committees, and management on project reviews, new drug discovery targets proposals, data supporting drug discovery projects, due diligence and evaluation of new technologies.

* Patch-clamp group leader. Line management of an associate; responsibility for the scientific and technical coaching of associate, undergraduate and PhD CASE student. * Accountable for the delivery of key data to drug discovery projects supported using patch-clamp electrophysiology in neuronal primary cultures and recombinant cell lines (e.g. nAChR ligands; D-serine/glycine modulation of NMDA receptors). * Responsible to coordinate and track in vitro biology activities for a pre-portfolio target of interest project reporting to project leader. * Evaluation of new/novel instrumentation for electrophysiological recordings; due diligence evaluation and visit to selected automated patch-clamp providers. * Presented to relevant project teams and management on project reviews, data supporting drug discovery projects, due diligence and evaluation of new technologies.

* Patch-clamp group leader. Line management of an associate; responsibility for the scientific and technical coaching of associate, team members and undergraduate students. * Established and implemented in vitro electrophysiology assays to support key drug discovery projects, including nAChR ligands.

* Established the patch-clamp technique in rodent bran slices within the in vitro electrophysiology laboratory. * Established models of synaptic transmission in brain slices for target validation studies. * Technical leadership for troubleshooting and upgrading of experimental set-up and software within the lab. Technical and scientific coaching and support to team members and undergraduate students.

* Research project: Characterisation of inward rectifier current in the weaver mouse. Fellowship granted by the INFM – Istituto Nazionale di Fisica della Materia, Biophysics Division. * Technical and scientific coaching and support to undergraduate and PhD students within the lab. * Run laboratory practices on nerve transmission for undergraduate students in Biology and Pharmacy degree courses.

* Independent agent for Nanounity LLC, a supplier of surface analytical solutions. Core technologies are microscopy, metrology and spectroscopy. * Scanning Electron Microscopes (SEM) * Correlative Raman and SEM imaging * Correlative fluorescence/SEM microscopy * Nanophotonics device measurement * Nano-indentation and Nano-mechanical testing * Optical and contact profilers * Atomic Force Microscopes (AFM)

* Scanning Electron Microscopes (SEM) * Correlative Raman and SEM imaging * Correlative fluorescence/SEM microscopy * Nanophotonics device measurement * Nano-indentation and Nano-mechanical testing * Optical and contact profilers * Atomic Force Microscopes (AFM)

Axion BioSystems innovative and award-winning products are designed to help biomedical researchers investigate the function of electrically active and cancer cells with a user-friendly, real-time recording, label-free in vitro assay. The Maestro Pro and Edge platform has been developed to increase throughput, functionality and information drawn from MEA (micro electrode array) measurements. At the same time, it makes the acquisition and analysis of electrophysiological data accessible to all researchers. The Maestro Z platform uses impedance-based cell analysis for continuous monitoring of your cells making it the ideal solution for immune-oncology, cell proliferation and variability, cell signalling assays and applications. Visit our website and explore how Axion MEA technology can be utilized to advance discoveries in modelling diseases, in drug discovery, in safety and toxicology studies and more. www.axionbiosystems.com gdefilippi@axionbiointl.com