Dave McGowan

Early stage small molecule drug discovery that ranges from hit finding to hit to lead optimization. Project leadership and team management experience.

Synthesis, purification and characterization of small molecule kinase inhibitors for use in oncology and immunology. Isolation by normal and reverse phase chromatography, characterization by LC-MS, and NMR. Co-author on 6 patents, 7 publications. Presented poster at internal symposium.

Acted as liaison between engineering, library optimization and technician groups to verify internal libraries before automated parallel synthesis. Characterization by LC-MS and NMR. Occasional building block synthesis. Trained new employees and managed two people. Member of library early-ADMET and SPE committees. Invented a new reaction block for reflux in parallel. US 1998 140145 Reaction Block and Cover. McGowan, D. C.; Mankarios, E. T.; Manley, E. M.; Werner, C.

Synthesis of alkaloid compounds as pharmaceutical candidates to treat cocaine addiction, supported by funding from NIDA (NIH). Isolation by column chromatography and prep-HPLC, and characterization by GC-MS, NMR, and IR. Member of the spill team, GMP trained.

2D NMR training to understand conformation of small molecules

Synthesis, purification and characterization of crown ethers. Isolation by normal phase chromatography, characterization by LC-MS, and NMR.