Darren Klugman, M.D., M.S.
Chief Clinical Officer @ CalmWave
About
Empowering Healthcare Transformation through Executive Leadership, Data-Informed Insights, and a Mindset of Continuous Innovation I have two decades of clinical and hospital leadership – driven by my passion for elevating patient outcomes through strategic thinking, data analytics, and a team-first approach. My background in pediatric cardiac intensive care has shown me that real progress happens when diverse teams rally around a common goal, and I’m committed to building a culture where people, processes, and data blend together to enable unparalleled results. I’ve led high-impact quality and safety initiatives, consistently pushing the boundaries of what's possible in healthcare. Whether advising biotech startups in drug and device development, guiding medtech innovation through my role as Chief Clinical Officer at CalmWave, or speaking at international conferences, my focus remains the same: to empower teams, leverage data, and spark forward-thinking ideas that advance clinical care on a global scale. My skills and areas of expertise include: • Quality Improvement and Patient Safety • Data-Driven Leadership and Decision-Making • Strategic Consulting and Board Advisory in MedTech and Biotech • Hospital Operations and Clinical Management • Cross-Functional Team Building and Mentorship • Hospital Change Management and Innovation I’m passionate about collaborating with bold thinkers to develop disruptive solutions in healthcare. If you share my drive for reshaping how we deliver care, let’s connect.
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United States
Hospital & Health Care
Startups, Executive Management, Program Development, Team Management, Business Development, Executive Leadership, Strategic Planning, Change Management, Organizational Leadership, Director level, Critical Care Medicine, Cardiology, Patient Safety, Healthcare Management, Pediatrics, Medicine, Medical Education, Clinical Research, Hospitals, Healthcare
Experience

Chief Clinical Officer
CalmWave is a hospital IT operations platform that empowers high-quality clinical operations by aligning AI solutions with real-world hospital workflows to optimize patient safety, minimize alarm fatigue, and optimize efficiency for frontline teams. I liaise with product development, data analysis, and sales, to bridge CalmWave’s AI-driven solutions with the needs of frontline providers and hospital systems. Our clinical, data analytics, and engineering teams refine product features based on feedback while demonstrating tangible value to prospective partners, transforming daily care delivery and improving outcomes and efficiency.

Startup Mentor
I mentor emerging health tech startups, offering insights from my experience leading clinical and quality/safety teams in complex hospital systems to guide scalable business strategies. By bridging the gap between visionary ideas and the practical realities of patient care delivery, I ensure that products are well positioned to be effective and transformative in a demanding healthcare market.

Director, Pediatric Cardiac Critical Care
Blalock-Taussig-Thomas Pediatric and Congenital Heart Center Johns Hopkins Children’s Center
1800 Orleans Street/Suite 6321 Baltimore, MD 21287
I established Maryland’s first dedicated pediatric cardiac intensive care unit, building a team culture that prioritized both patient outcomes and collaboration. Emphasizing open communication, I empowered my team to achieve performance metrics on par with leading national programs. To deliver the highest standards of care, I consistently refined clinical protocols and safety measures. This role was unique because it allowed me to demonstrate how building a team focused on collaboration and culture can achieve extraordinary results in a high-intensity clinical setting.

Medical Director, Cardiac Intensive Care Unit
Washington, District of Columbia, United States
I directed a multidisciplinary critical care team responsible for some of the most complex pediatric cardiac cases. Data-driven insights guided my decisions, and I championed initiatives that consistently improved patient quality and safety. By recognizing the strengths of each team member and positioning them for success, my staff and I delivered top-tier, patient and family experience with the most complex fragile patients.

Director of Quality & Outcomes, Children's National Heart Institute
Washington, District of Columbia, United States
I led a comprehensive program to enhance patient quality and outcomes by combining advanced data analytics with multidisciplinary team engagement to identify areas for improvement. The initiatives I influenced reduced critical events, secured national recognition, and cultivated an environment where accountability and transparency were top priorities. I encouraged diverse voices and perspectives from all levels of the organization to drive innovation and sustainable progress. By uniting people under a shared vision for quality, the program quickly gained national prominence and maintained exceptional outcomes.

Attending, Cardiac Intensive Care, Divisions of Critical Care Medicine & Cardiology
Washington, District of Columbia, United States
I delivered care directly to pediatric patients with complex acquired and congenital heart disease, ensuring a very high standard for patient and family experience. Like any patient-facing position, this role required quick, complex decision making and a thoughtful approach to the patient and family experience. Mentoring fellows and junior physicians was equally as rewarding as treating patients for me. I shared evidence-based best practices to strengthen my team’s collective commitment to compassionate and high quality patient care.

Director, Medical Safety
Washington, District of Columbia, United States
I guided multidisciplinary team efforts to enable the safe administration of medications – partnering with pharmacy, nursing, and biomedical engineering teams to streamline processes. I had my eye on both system-level vulnerabilities and day-to-day clinical practices.

Associate Professor of Pediatrics
Washington, District of Columbia, United States
I balanced clinical practice with academic responsibilities, shaping curricula that incorporated both theoretical instruction and hands-on experiences. Encouraging students to engage with cutting-edge research, I nurtured their growth to make them well-rounded clinicians. I recognized early that mentorship was critical, and I emphasized critical thinking and empathetic care as the hallmarks of medical professionalism. Seeing students evolve into capable physicians was an enduring highlight of my academic career.

Board Member
The C.L.A.Y. Foundation
Darren Klugman, M.D., M.S.'s Contact Information
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