Danquan Wang

• Developed and prepared solution/suspension/emulsion/micelle/liposome formulation through PO, IV, IN, SQ administration to support internal and external PK, efficacy, toxicity studies to enable small molecule drug selection in collaboration with senior scientists and project teams while maintaining high data integrity via eLN system • Designed or executed protocols to perform pre-formulation and formulation characterization including pH, osmolarity, particle size, solubility, stability, solid-state properties via UPLC-MS (QDa, CAD detector), osmometer, DLS, PXRD, TGA, DSC, DVS, SEM • Optimized preparation method of lipid nanoparticles for gene delivery, conducted UPLC-based analytical method development for measuring drug loading/release profile, encapsulation efficiency and stability

• Utilized electrospinning method to fabricate various polymer composite nanofibers (PCL/PCL-MA/GelMA), evaluated their bactericidal activity on S. aureus, P. aeruginosa and MRSA via ROS assay, colony counting and SEM, conducted degradation test under enzyme treatment • Participated in research on the antibacterial activity of self-assembled nano-peptide amphiphiles (SANPAs), determined CMC, characterized its morphology and surface charge via DLS, TEM, conducted colony counting and MTS assay to evaluate antibacterial and cytotoxicity properties • Assisted on general lab management including monitoring lab safety issue and processing lab orders

• Conducted thesis research on the self-assembly of amphiphilic Vitamin E Succinate phospholipid (Di-VES-GC) conjugate • Designed synthesis schemes to evaluate the efficiency of different catalyst systems, optimized purification procedure, characterized the purity and structure of the prodrug Di-VES-GC via ESI-MS, HPLC, NMR and FT-IR • Utilized thin-film dispersion method to prepare liposome nanoparticles from the prodrug Di-VES-GC and characterized its self-assembly properties via CMC measurement, DLS, TEM and Cryo-EM