Dan Stettler

- Led successful effort to develop a novel clinical biomarker for neurological target - Authored relevant sections of regulatory communications (IND Briefing Book, IB, DD Reports) - Developed PD assay to support advancement of compound from Lead Op to PCC nomination - Analyzed PK/PD data to improve strategy for achieving greater therapeutic index - Co-led effort to identify novel targets in the brainstem for treatment of obesity utilizing pipeline integrating single cell sequencing, computation, behavioral in vivo pharmacology, and histological brain activity mapping - Performed safety assessments of novel brainstem targets and proposed Go/No-Go’s to leadership

- Led successful early discovery effort to identify targets expressed by the vagus nerve eliciting brain neurotransmitter release - Generated key data using combined mouse transgenic models, chemogenetics, in vivo pharmacology, behavioral assessment, and brain fiber photometry - Collaborated closely with in-house chemistry team and managed CRO studies - Guided establishment of cellular resolution vagus nerve imaging and generated code for data analysis, collation, and presentation

- Led successful early discovery effort to identify targets activating the carbohydrate- or lipid-induced post-oral reward pathways - Developed novel behavioral assays incorporating intra-GI tract compound delivery and automated consumption monitoring - Established in vivo microdialysis, histological brain activity mapping capabilities, and transgenic mouse models - Collaborated closely with in-house chemistry team and managed CRO studies - Communicated strategy to potential external partners

- Identified fundamental characteristics of olfactory cortex odorant processing in the lab of Richard Axel (Nobel Prize 2004). - Cited in the premier neuroscience textbook (Principles of Neural Science, 6th Edition, Kandel et. al.)

- Characterized visual cortical circuitry mediating contour perception in the lab of Charles Gilbert - Characterized plasticity in adult visual cortex - Developed multiphoton microscopy techniques to image neurons in the brains of living nonhuman primates - Cited in the premier neuroscience textbook (Principles of Neural Science, 6th Edition, Kandel et. al.)