Christine Z. Yang, MPH

-As Asset Lead, partner with Clinical Development leadership to drive cross-functional strategic planning and lifecycle management for TYRA-300 franchise across skeletal dysplasia and oncology portfolio -Lead Program Management team supporting strategic and operational cross-functional teams, strategic partnerships, and oversight forums across the Tyra portfolio

-PM Lead across portfolio of oncology and rare disease programs targeting FGFR mutation-driven indications with novel, highly selective small molecule inhibitors -Drove the design and implementation of corporate governance and program team structure, reporting forums and dashboard templates, publication planning processes, and other best practices -Led program teams through CDP development, data reviews, development decision gates, 3 new INDs cleared within 6 months, and content preparation for leadership and Board of Directors meetings -Alliance Manager for strategic partnerships across oncology portfolio, including multiple global companion diagnostic development projects

-Drives strategic planning for multiple programs across alloCAR T portfolio in partnership with Asset Leaders and R&D leadership -Leads Clinical Program Management team supporting various programs across R&D organization; prioritizes consistency, best practices, and coaching/mentorship -Supports R&D leadership team, governance forums, SAB and BOD activities, and strategic alliance/BD initiatives

-Drove strategic planning and excellence in execution for asset and study level teams -Led development of integrated project plans, timelines, and PM tools/best practices -Alliance manager for collaboration with SpringWorks Therapeutics (alloCAR + gamma secretase inhibitor combination study)

Established PM practices in support of two project teams launching first in human autoCAR T programs in solid tumor indications and one team developing alloCAR T capabilities.

-Managed cross-functional late-stage Development Core Team overseeing a portfolio of global registrational clinical trials testing immuno-oncology biologics, small molecules, and combination therapies in solid tumor indications (gastric and esophageal carcinomas). -Developed meeting objectives, agendas, minutes, action items, and escalation to governance to support achievement of team and corporate goals. -Drove completion of key activities supporting budgeting, resource allocation, reporting, risk management, goal setting, and portfolio prioritization. -Created and actively managed project plans and timelines using MS Project and data visualization tools; built standardized templates, definitions, and best practices for implementation across the global PM organization. -Collaborated across functions and with identified vendors to build, test, and launch tools, work instructions, and enterprise software applications to improve operational efficiency both within PM function and across the organization.

Project and Program Management: -Managed cross-functional teams and project plans in the research and development of preclinical and clinical stage oncology biologics programs in both solid tumor and hematology oncology indications. -Supported joint project team’s achievement of proof of concept for Padcev (enfortumab vedotin) in metastatic bladder cancer; product went on to receive Breakthrough Designation, Accelerated and Full Approval from FDA. -Communicated effectively to build engagement across functions and levels in a matrix organization to ensure efficient completion of critical path activities and program milestones. -Supported alliance management activities with business development partners. -Designed and implemented process improvement projects and tools to optimize efficiency in company operations. -Facilitated monthly and quarterly reporting, annual planning, and performance evaluation activities in relation to global company objectives. Clinical Operations: Oversaw execution of a randomized Phase 2 clinical trial comparing an ADC monotherapy regimen to standard of care in Renal Cell Carcinoma across dozens of sites in North America; activities included eligibility, enrollment, monitoring, reporting, budgeting and contracting, as well as the performance of CRO and CRA resources.

Directly managed team of regional supervisors, both remote and in-house, to oversee a part-time remote field staff of 1500 scribes nationally. Responsible for all activities relating to interviewing, hiring, mentorship, discipline, and attendance for regional supervisor team, and all escalated issues pertaining to their remote team operations 24/7. Standardized team use of scheduling software, reporting tools, CRM software, and written/verbal communication. Indirectly managed teams and projects across functions to support human resources, payroll, recruitment, training, and marketing/communications.

Established and maintained excellent relationships with over twenty active clients, consistently growing the book of business in areas of emergency medicine, urgent care, and ambulatory clinics throughout Southern California. Strategically focused services to optimize patient care workflows and revenue cycle management during daily operations, as well as operational transitions such as EMR implementations and changes in hospital ownership, billing companies, and medical group contracting. Worked closely with sales team to support proposals, presentations, and CRM database maintenance/reporting.

Managed implementation and customer success for a variety of medical practices adopting the PatientPad wireless patient documentation solution. This included coordinating the customization of software configurations and integrations with other practice management and electronic health record systems, as well as advising regarding best practices and training practice staff. Facilitated the expansion of the technology solution into targeted marketing efforts and patient experience ratings and reviews collection for client practices and corporate advertising partners.

David Geffen School of Medicine/CASIT research project evaluating utilization and cost-effectiveness of Ronald Reagan UCLA Medical Center's integrated operating room technology.

Contributed to a variety of hospital operations projects and executive meetings, including Emergency Department front-end re-design, flu epidemic planning, performance benchmarking dashboards, and market segmentation research.