Colin Gauvin

Structural Biologist - Responsible for high throughput cryo-EM of GPCRs (up to 6+ structures/weeks, in tandem with SAR cycles) including construct design, protein expression and purification, data collection and analysis - Structural analysis of protein : ligand complexes - Collaboration with computational chemistry and medicinal chemistry to enable structure-driven drug design

- Created a state of the art cryo-EM facility from scratch utilizing a 200 kV Talos Arctica and Gatan K3 camera - SmartScope contributor since 2023, fully automated, throughputs > 12,000 images/day, resolution > 2.0 Å (highest 1.86 Å, PfDPSL) - Developed supporting computational infrastructure for data storage, transfer, and processing - Developed all SOPs and protocols, trained all users

• Working with clients to plan, design, and implement websites to fit their needs • Developing custom web software to meet client needs • Computer system administration, both for clients and for the business • Planned and implemented a web-server solution for the business

● Perform distillations, digestions, colorimetric analyses, and incubations in accordance with standard operating procedures ● Ensure accurate results by implementing quality control standards when required ● Collect, interpret, and enter data using Element LIMS

Structural biology, cryo-EM