Chungwen Liang

1. Force field development of chemically-modified nucleic acids 2. Simulation/modeling of chemically-modified oligonucleotides (ASO, aptamer, and siRNA) 3. Development of toxicity profiles of oligonucleotide-based medicines (OBMs)

Computational and Modeling Core of the UMass Institute for Applied Life Sciences (IALS) provides expert consultative and collaborative services to both academic and industrial partners. As a collaborative partner, we contribute directly to research and development, such as performing simulations, interpreting results, providing actionable decisions, and preparing materials for scientific manuscripts and grant applications. We also assist scientists who are unfamiliar with computational tools and high-performance computing to apply these techniques in their research projects. Our expertise includes ab-initio/classical molecular dynamics simulations, quantum chemistry/electronic structure calculations, computational spectroscopy, small molecule design, and protein-ligand docking and screening. Please visit our website: https://www.umass.edu/ials/computational-modeling

IR spectrum Modeling